Alteration of Regional Homogeneity within the Sensorimotor Network after Spinal Cord Decompression in Cervical Spondylotic Myelopathy: A Resting-State fMRI Study.
Alteration of Regional Homogeneity within the Sensorimotor Network after Spinal Cord Decompression in Cervical Spondylotic Myelopathy: A Resting-State fMRI Study.
复制标题
脊髓型颈椎病脊髓减压后感觉运动网络内区域均匀性的改变：静息态功能磁共振成像研究
DOI：
10.1155/2015/647958
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发表时间：
2015
影响因子：
--
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Tan Y;Zhou F;Wu L;Liu Z;Zeng X;Gong H;He L
目前缺乏对脊髓减压后恢复后感觉运动网络（SMN）内神经元适应性变化功能的纵向研究。区域同质性（ReHo）可能为充分理解脑脊髓炎相关的功能性神经同步改变提供关键信息。本研究的目的是评估减压前和减压后CSM和健康对照（HC）静息状态-功能MRI （rs-fMRI）的ReHo变化及其与临床指标的相关性。与HC相比，减压前CSM在左侧初级感觉皮层和初级运动皮层（PostG/PreG）的ReHo明显降低，而在右侧顶叶上小叶（SPL）的ReHo明显增强。与HC患者相比，减压后CSM左侧PostG/PreG的ReHo升高，右侧SPL的ReHo明显降低。CSM减压前后ReHo区异常与日本骨科协会（JOA）评分、颈部残疾指数（NDI）评分及病程无显著相关性（P < 0.05）。这一结果证明了CSM中SMN的区域均匀性被破坏。大脑中的这种适应性变化可能有利于保存颈髓减压前后的感觉运动网络和SMN中独立于ReHo的临床症状。
There is a lack of longitudinal research to evaluate the function of neurons' adaptive changes within the sensorimotor network (SMN) following recovery after cervical cord decompression. Regional homogeneity (ReHo) may provide information that is critical to fully understand CSM-related functional neural synchrony alterations. The purpose of this study was to assess the ReHo alterations of resting state-functional MRI (rs-fMRI) within pre- and postdecompression CSM and healthy controls (HC) and its correlations with clinical indices. Predecompression CSM demonstrated a significantly lower ReHo in the left primary sensory cortex and primary motor cortex (PostG/PreG) but enhanced ReHo in the right superior parietal lobule (SPL) compared with HC. In comparison with predecompression CSM, the postdecompression CSM showed increased ReHo in the left PostG/PreG but significantly lower ReHo in the right SPL compared with HC patients. Abnormal ReHo regions in pre- or postdecompression CSM showed no significant correlation with the Japanese Orthopaedic Association (JOA) scores, Neck Disability Index (NDI) scores, and disease duration (P > 0.05). This result demonstrated disrupted regional homogeneity within SMN in CSM. This adaptive change in the brain may favor the preservation of sensorimotor networks before and after cervical cord decompression and clinical symptoms independent of ReHo within SMN.