On-beam synchrony in the cerebellum as the mechanism for the timing and coordination of movement
On-beam synchrony in the cerebellum as the mechanism for the timing and coordination of movement
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DOI：
10.1073/pnas.0609966104
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发表时间：
2007-05-01
影响因子：
11.1
通讯作者：
Keating, J. G.
中科院分区：
文献类型：
--
作者：
Heck, D. H.;Thach, W. T.;Keating, J. G.
in trained reaching rats, we recorded simple spikes of pairs of Purkinje cells that, with respect to each other, were either aligned on a beam of shared parallel fibers or instead were located off beam. Rates of simple spike firing in both on-beam and off-beam Purkinje cell pairs commonly showed great variety in depth of modulation during reaching behavior. But with respect to timing, on-beam Purkinje cell pairs had simple spikes that were tightly time-locked to each other (either delayed or simultaneous) and to movement, despite the variability in rate. By contrast, off-beam Purkinje cell pairs had simple spikes that were not time-locked to each other, neither delayed nor simultaneous. We discuss the implications of these observations for the cerebellar role in timing and coordinating movement.
