Programmed cell death in invertebrates
Programmed cell death in invertebrates
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DOI：
10.1016/s0959-437x(96)90007-6
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发表时间：
1996-02-01
影响因子：
4
通讯作者：
Hengartner, MO
中科院分区：
文献类型：
--
作者：
Hengartner, MO
在秀丽隐杆线虫和黑腹果蝇中程序性细胞死亡的遗传学研究已经导致了几个无脊椎动物细胞死亡基因的鉴定。In C.线虫、CED-3和CED-4的功能是杀死细胞，而CED-9保护细胞免于死亡。在果蝇中，reaper基因和hid基因并行作用，促进细胞死亡。这些基因的特性表明，程序性细胞死亡的过程是进化上保守的，并揭示了细胞凋亡机制的分子本质。
Genetic studies of programmed cell death in Caenorhabditis elegans and Drosophila melanogaster have led to the identification of several invertebrate cell death genes. In C. elegans, ced-3 and ced-4 function to kill cells, whereas ced-9 protects cells from death. In Drosophila, the genes reaper and hid act in parallel to promote cell death. Characterization of these genes has revealed that the process of programmed cell death is evolutionarily conserved and has shed light on the molecular nature of the apoptotic machinery.