Prolactin concentrations in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis
Prolactin concentrations in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis
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DOI：
10.1016/j.schres.2011.07.025
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发表时间：
2012-01-01
影响因子：
4.5
通讯作者：
Kirkpatrick, Brian
中科院分区：
文献类型：
--
作者：
Garcia-Rizo, Clemente;Fernandez-Egea, Emilio;Kirkpatrick, Brian
背景：以前的研究发现，未接受过抗精神病药物治疗的精神分裂症患者催乳素浓度升高。然而，其他激素的作用，以及潜在的混杂变量，如性别和吸烟，没有被考虑。（13名女性和20名男性）和匹配的对照组（12名女性和21名男性）测定催乳素，以及影响催乳素浓度的其他三种激素：促甲状腺激素刺激激素（TSH）、生长激素释放肽和皮质醇。结果：患者的催乳素浓度显著较高：女性患者的平均值[SD]为37.1 ng/mL [24.9]，女性对照受试者为13.5 ng/mL [7.2]（p=.001），而男性患者的平均值为15.3 ng/mL [9.5]，男性对照受试者为7.6 ng/mL [2.2]（p=.006）。患者和对照组的TSH、ghrelin或皮质醇浓度没有差异。组间差异不能归因于年龄，性别，吸烟，体重指数，种族，或origin.Conclusions的家庭的社会经济地位的差异：增加催乳素浓度在抗精神病药初治患者似乎不是由于重要的混杂变量，或升高的TSH，生长激素释放肽，或皮质醇的影响。(C)2011爱思唯尔有限公司版权所有。
Background: Previous studies have found increased prolactin concentrations in antipsychotic-naive patients with schizophrenia. However, the roles of other hormones, and of potentially confounding variables such as gender and smoking, have not been considered.Methods: Blood from newly diagnosed, antipsychotic-naive patients with nonaffective psychosis (13 women and 20 men) and matched controls (12 women and 21 men) was assayed for prolactin, as well as three other hormones that impact prolactin concentrations: thyrotropin-stimulating hormone (TSH), ghrelin, and cortisol.Results: Patients had significantly higher prolactin concentrations: female patients had a mean [SD] of 37.1 ng/mL [24.9] vs. 13.5 ng/mL [7.2] for female control subjects (p=.001), while male patients had a mean of 15.3 ng/mL [9.5] vs. 7.6 ng/mL [2.2] for male control subjects (p=.006). Patients and control subjects did not differ on concentrations of TSH, ghrelin, or cortisol. The group differences could not be attributed to differences in age, gender, smoking, body mass index, ethnicity, or the socioeconomic status of the family of origin.Conclusions: Increased prolactin concentrations in antipsychotic-naive patients do not appear to be due to important confounding variables, or to the effects of elevated TSH, ghrelin, or cortisol. (C) 2011 Elsevier B.V. All rights reserved.