Morphological and morphometric alterations of Cajal-Retzius cells in early cases of Alzheimer's disease: A Golgi and electron microscope study
Morphological and morphometric alterations of Cajal-Retzius cells in early cases of Alzheimer's disease: A Golgi and electron microscope study
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DOI：
10.1080/00207450590901396
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发表时间：
2005-07-01
影响因子：
2.2
通讯作者：
Baloyannis, SJ
中科院分区：
文献类型：
--
作者：
Baloyannis, SJ
Cajal-Retzius细胞是大脑皮层第一层的主要神经元，通过分泌纤维素在细胞发育和神经回路形成中起着重要作用。在阿尔茨海默病的早期病例中，基于银浸渍技术和电子显微镜对颞叶同皮质层1的形态学和形态测量学研究显示Cajal-Retzius细胞的数量急剧下降。由于Cajal-Retzius细胞和reelin是海马和大脑同皮质中突触发生的重要因素，因此它们的丢失可能与阿尔茨海默病的突触病理学和多因素致病途径有关。
Cajal-Retzius cell is the prominent neuron of layer 1 of the cortex, playing a crucial role in cellular development and neuronal circuit formation, by secretion of reelin. In early cases of Alzheimer's disease the morphological and morphometric study of layer 1 of the temporal isocortex, based on silver impregnation techniques and electron microscopy, revealed a dramatic decline of the number of Cajal-Retzius cells. Because Cajal-Retzius cells and reelin are important factors for the synaptogenesis in the hippocampus and the brain isocortex, their loss may be implicated in the synaptic pathology and the multifactorious pathogenetic pathways of Alzheimer's disease.