Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications.
Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications.
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DOI：
10.1158/1078-0432.ccr-16-0028
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发表时间：
2016-08-01
期刊：
影响因子：
--
通讯作者：
Wang SE
中科院分区：
文献类型：
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作者：
Chin AR;Wang SE
越来越多的工作已经证明，癌症转移不是一个随机的自发事件;相反，它是一系列引发步骤的高潮，通过这些步骤，肿瘤细胞的亚群获得侵袭性特征，同时准备一个允许的环境，称为转移前的小生境，其中可能发生远处转移。来自原发性肿瘤的信号动员和适应免疫细胞，并直接与远处的小生境细胞沟通，以诱导靶器官中的广泛适应，包括诱导血管生成、炎症、细胞外基质重塑和代谢重编程。这些相互作用共同促进了转移前小生境的形成，该小生境由通过我们刚刚开始理解的复杂信号网络连接的驻留和招募的免疫细胞、内皮细胞和基质细胞的可变混合物组成。在这里，我们总结了关于癌症如何诱导和引导这种转移前小生境形成的最新发现，以及可能导致更好地理解和有效治疗转移性疾病的潜在预后标志物和治疗靶点。
A growing body of work has demonstrated that cancer metastasis is not a random spontaneous event; rather it is the culmination of a cascade of priming steps through which a sub-population of the tumor cells acquires invasive traits while readying a permissive environment, termed the pre-metastatic niche, in which distant metastases can occur. Signals from the primary tumor mobilize and adapt immune cells as well as directly communicate with distant niche cells to induce a broad spectrum of adaptations in target organs, including the induction of angiogenesis, inflammation, extracellular matrix remodeling, and metabolic reprogramming. Together these interactions facilitate the formation of a pre-metastatic niche composed of a variable mix of resident and recruited immune cells, endothelial cells, and stromal cells connected through a complex signaling network that we are only beginning to understand. Here we summarize the latest findings on how cancer induces and guides the formation of this pre-metastatic niche as well as potential prognostic markers and therapeutic targets that may lead to a better understanding and effective treatment of metastatic disease.