Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing
Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing
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DOI：
10.1183/09031936.00021810
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发表时间：
2010-10-01
影响因子：
24.3
通讯作者：
Miller, M. A.
中科院分区：
文献类型：
--
作者：
Bourjeily, G.;Raker, C. A.;Miller, M. A.
妊娠期的生理变化可能使女性更易发生睡眠呼吸障碍（SDB）或预防睡眠呼吸障碍，但评估妊娠期SDB症状结局的研究很少。本研究采用多变量呼吸暂停预测指数对随机选择的产后妇女进行横断面调查，以评估妊娠期SDB症状的患病率及其与妊娠结局和新生儿结局的关系。进行记录审查，包括人口统计学和病史。主要结局指标包括妊娠和新生儿结局。招募了1,000名受试者。平均± SD年龄为29.1 ± 6.1岁。回归分析中使用的因素包括年龄、体重指数、糖尿病、慢性高血压、多胎妊娠、吸烟和肾脏疾病。35.1%的受试者存在打鼾。多变量回归分析后，SDB症状与妊娠高血压和先兆子痫（校正OR 2.3，95% CI 1.4-4.0）、妊娠期糖尿病（校正OR 2.1，95% CI 1.3-3.4）和计划外剖腹产（校正OR 2.1，95% CI 1.4-3.2）的可能性较高相关。调整年龄和多胎妊娠后，喘息可能与早产的可能性较高相关（调整OR 1.8，95%CI 1.1-3.2），但这种相关性似乎是由先兆子痫介导的。SDB的症状在妊娠期很常见，与妊娠期高血压疾病、妊娠期糖尿病和计划外剖腹产的可能性较高相关。
The physiological changes of pregnancy may predispose females to develop sleep-disordered breathing (SDB) or protect against it. Studies evaluating outcomes of SDB symptoms in pregnancy are scarce. The goal of this study was to evaluate the prevalence of SDB symptoms in pregnancy and their relationship with pregnancy and neonatal outcomes.A cross-sectional survey of randomly selected immediate postpartum females was performed using the multivariable apnoea prediction index. Record review, including demographics and medical history, was performed. Main outcome measures included pregnancy and neonatal outcomes.1,000 subjects were recruited. Mean +/- SD age was 29.1 +/- 6.1 yrs. Factors used in the regression analysis included age, body mass index, diabetes, chronic hypertension, multifetal gestations, smoking and renal disease. Snoring was present in 35.1% of subjects. Symptoms of SDB were associated with a higher likelihood of pregnancy-induced hypertension and pre-eclampsia (adjusted OR 2.3, 95% CI 1.4-4.0), gestational diabetes (adjusted OR 2.1, 95% CI 1.3-3.4) and unplanned Caesarean deliveries (adjusted OR 2.1, 95% CI 1.4-3.2) after multivariable regression analysis. Gasping may have been associated with a higher likelihood of preterm delivery, after adjusting for age and multifetal pregnancies (adjusted OR 1.8, 95% CI 1.1-3.2) but this association appeared to be mediated by pre-eclampsia.Symptoms of SDB are common in pregnancy and associated with a higher likelihood of gestational hypertensive disorders, gestational diabetes and unplanned Caesarean deliveries.