The correlation between Ki-67 with other prognostic factors in breast cancer: A study in Iranian patients
The correlation between Ki-67 with other prognostic factors in breast cancer: A study in Iranian patients
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DOI：
10.4103/0971-5851.180136
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发表时间：
2016-04-01
影响因子：
0.2
通讯作者：
Sadeghi, Edris
中科院分区：
文献类型：
--
作者：
Madani, Seyed-Hamid;Payandeh, Mehrdad;Sadeghi, Edris
背景：尽管乳腺癌 (BC) 是一个主要的健康问题，但很少有研究描述其在中东的特征。目的：本研究的目的是评估 Ki-67 作为 BC 预后标志物的用途和价值，并评估 Ki-67、临床和组织病理学参数之间的关联。对象和方法：在一项回顾性研究中，我们在伊朗克尔曼沙赫市的研究中纳入了 260 名 BC 妇女和浸润性导管癌患者。年龄、肿瘤大小、淋巴结受累、组织学分级、核分级和血管侵犯是许多患者的其他决定因素。结果：诊断时的平均年龄为 47.6 岁（范围为 24-84 岁），其中 100% 为女性。在确定肿瘤大小的 243 名患者中，207 名患者 (85.2%) 肿瘤大小 >= 2 cm，36 名患者 (14.8%) 肿瘤大小 = 20%，具有较高的核分级、p53 阳性和 HER2 阳性。 Ki-67与肿瘤类型之间存在相关性（P = 0.009）。结论：较高的 Ki-67 与较高的核分级、p53 阳性和 HER2 阳性有直接显着相关性。此外，与其他亚型相比，三阴性患者的 Ki-67 更高。
Context: Despite the fact that breast cancer (BC) is a major health issue, very few studies describe its characteristics in the Middle East. Aim: The aim of this study was to evaluate the use and value of Ki-67 as a prognostic marker in BC and associations between Ki-67, clinical, and histopathological parameters were evaluated. Subjects and Methods: In a retrospective study, 260 BC women and invasive ductal carcinoma were included to our study in Kermanshah city, Iran. Age, tumor size, lymph node involvement, histological grade, nuclear grade, and vascular invasion were other factors that determined in a lot of patients. Results: The mean age at diagnosis was 47.6 years (range, 24-84 years) with 100% female. Of 243 patients that tumor size was determined for them, 207 patients (85.2%) had tumor size >= 2 cm, and 36 patients (14.8%) had size = 20% have higher nuclear grade, p53-positive, and HER2-positive. There was correlation between Ki-67 with type of tumor (P = 0.009). Conclusions: The higher Ki-67 has a direct significant correlation with higher nuclear grade, p53-positive, and HER2-positive. Furthermore, triple negative patients have higher Ki-67 compared to other subtypes.