Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory
Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory
复制标题
DOI：
10.1016/j.celrep.2015.03.017
复制
发表时间：
2015-04-14
期刊：
影响因子：
8.8
通讯作者：
Inokuchi, Kaoru
中科院分区：
文献类型：
--
作者：
Ohkawa, Noriaki;Saitoh, Yoshito;Inokuchi, Kaoru
记忆被认为是作为学习过程中激活的细胞集合而存储在大脑中的。尽管细胞群的光刺激会触发相应记忆的检索，但目前尚不清楚信息关联如何在细胞群水平上发生。在小鼠身上使用没有任何感觉输入的光遗传学刺激，我们发现存储的、不相关的情境和恐惧信息之间的人为关联是通过与存储的信息相对应的不同细胞群的同步激活而产生的。这种人工关联与生理相关记忆具有共同的特征，例如 N-甲基-D-天冬氨酸受体活性和蛋白质合成依赖性。这些发现表明信息的关联是通过不同细胞群的同步活动来实现的。这种机制可能是通过将新信息整合到预先存在的网络中以形成高质量的新记忆来进行记忆更新的基础。
Memory is thought to be stored in the brain as an ensemble of cells activated during learning. Although optical stimulation of a cell ensemble triggers the retrieval of the corresponding memory, it is unclear how the association of information occurs at the cell ensemble level. Using optogenetic stimulation without any sensory input in mice, we found that an artificial association between stored, non-related contextual, and fear information was generated through the synchronous activation of distinct cell ensembles corresponding to the stored information. This artificial association shared characteristics with physiologically associated memories, such as N-methyl-D-aspartate receptor activity and protein synthesis dependence. These findings suggest that the association of information is achieved through the synchronous activity of distinct cell ensembles. This mechanism may underlie memory updating by incorporating novel information into pre-existing networks to form qualitatively new memories.