Slow cortical potential shifts preceding sensorimotor interactions
Slow cortical potential shifts preceding sensorimotor interactions
复制标题
DOI：
10.1016/j.brainresbull.2004.11.023
复制
发表时间：
2005-04-30
影响因子：
3.8
通讯作者：
Rossini, PM
中科院分区：
文献类型：
--
作者：
Babiloni, CB;Brancucci, A;Rossini, PM
众所周知，皮层神经元的同步化是通过躯体感觉和感觉运动事件之间的时间顺序相互作用来调节的（“门控”）。本研究测试的假设，这种相互作用的预期过程中增加皮层神经元的同步所揭示的负事件相关电位（contingent negative variation，CNV）。在14名受试者中记录了高分辨率脑电图数据（128电极）。在“感觉运动相互作用”条件下，受试者等待左手的躯体感觉电刺激，伴随着Go或NoGo刺激（50%的Go试验触发右手运动）。在控制条件下，Go/NoGo刺激跟随1.5 s的体感刺激。脑电数据空间增强表面拉普拉斯估计。在对照组中，CNV仅出现在躯体感觉刺激和Go/NoGo任务之间的前期（即躯体感觉刺激前无CNV）。它在空间上定位于可能的运动反应的对侧的主要感觉运动区。在“感觉运动相互作用”条件下，CNV先于伴随的躯体感觉刺激和Go/NoGo任务，并分布到额中央中线以外的对侧感觉运动区。这些结果表明，预期的过程中的感觉运动的相互作用增加了同步的皮层神经元在额中央中线，可能是由于机制subserving自上而下的注意力过程。(c)2005年爱思唯尔公司All rights reserved.
It is well known that synchronization of cortical neurons is modulated ("gating") by the chronological interaction between somatosensory and sensorimotor events. This study tested the hypothesis that the anticipatory processes for this interaction increase the synchronization of cortical neurons as revealed by negative event-related potentials (contingent negative variation, CNV). High-resolution electroencephalographic data (128 electrodes) were recorded in 14 subjects. In the "sensorimotor interaction" condition, the subjects were waiting for a galvanic somatosensory stimulation at the left hand concomitant with a Go or NoGo stimulus (50% of Go trials triggering right hand movements). In the control condition, the Go/NoGo stimulus followed the somatosensory stimulation of 1.5 s. The electroencephalographic data were spatially enhanced by surface Laplacian estimation. In the control condition, the CNV was observed only in the foreperiod between the somatosensory stimulation and Go/NoGo task (i.e. no CNV before the somatosensory stimuli). It was spatially localized in the primary sensorimotor area contralateral to the possible motor response. In the "sensorimotor interaction" condition, the CNV preceded the concomitant somatosensory stimulation and Go/NoGo task and was distributed to the frontocentral midline other than the contralateral sensorimotor area. These results suggest that the anticipatory processes for sensorimotor interactions increase the synchronization of cortical neurons in the frontocentral midline, possibly due to mechanisms sub-serving top-down attentional processes. (c) 2005 Elsevier Inc. All rights reserved.