Corneal graft outcome study
Corneal graft outcome study
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DOI：
10.1097/00003226-200103000-00002
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发表时间：
2001-03-01
期刊：
影响因子：
2.8
通讯作者：
Slomovic, AR
中科院分区：
文献类型：
--
作者：
Sit, M;Weisbrod, DJ;Slomovic, AR
目的。在我们的患者群体中，确定总体的2年和5年的角膜移植物存活率，并确定角膜移植物失败的危险因素。对多伦多西医院75年间由一位外科医生施行角膜移植手术的696例患者进行了回顾分析。共有468只眼符合这项研究的纳入标准。总体而言，2年和5年移植物存活率分别为78.8%和63.5%。单因素分析显示，患者年龄、性别、青光眼病史、术前诊断、手术方式和术后因素均与移植物存活率显著相关。在多变量分析中，确定了6个独立的移植物失败预测因素：术前诊断、移植物新生血管、周围前粘连的存在、性别、一次或多次排斥事件的发生以及受者接受角膜移植时的年龄。在接受角膜移植的患者群体中，移植失败的风险可能会有很大不同。这项研究的结果与文献中角膜移植失败的危险因素一致，可以作为外科医生和患者的预后指南。
Purpose. To determine overall 2- and 5-year corneal graft survival rates and to identify risk factors for corneal graft failure in our patient population.Methods. A retrospective chart review of 696 patients undergoing corneal transplantation performed by a single surgeon at The Toronto Western Hospital over a 7.5-year period.Results. A total of 468 eyes met the inclusion criteria for this study. Overall, the 2- and 5-year graft survival rates were 78.8% and 63.5%, respectively. In a univariate analysis, patient age, gender, history of glaucoma, preoperative diagnosis, type of operative procedure, and postoperative factors all were shown to be significantly associated with graft survival. In a multivariate analysis, six independent predictors of graft failure were identified: preoperative diagnosis, neovascularization of the graft, the presence of peripheral anterior synechiae, gender, occurrence of one or more rejection episodes, and age of the recipient at the time of corneal transplantation.Conclusions. Risk of graft failure can vary substantially within a population of patients receiving a corneal transplant. The outcomes of this study concur with the risk factors for corneal graft failure in the literature and can be used as prognostic guidelines for both surgeons and patients.