DIFFERENCE IN CLINICAL-FEATURES AND HLA ANTIGENS BETWEEN FAMILIAL AND NONFAMILIAL VITILIGO OF NON-SEGMENTAL TYPE
DIFFERENCE IN CLINICAL-FEATURES AND HLA ANTIGENS BETWEEN FAMILIAL AND NONFAMILIAL VITILIGO OF NON-SEGMENTAL TYPE
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DOI：
10.1111/j.1365-2133.1993.tb03167.x
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发表时间：
1993-10-01
影响因子：
10.3
通讯作者：
OTSUKA, F
中科院分区：
文献类型：
--
作者：
ANDO, I;CHI, HI;OTSUKA, F
在所研究的131名非节段性白癜风患者中，29名(22%)有这种疾病的家族史。分析其临床特点和人类白细胞抗原，并对家族性和非家族性、非节段性白癜风患者进行比较。家族性皮损发生的时间明显早于非家族性皮损。HLAB46与家族性非节段性白癜风显著相关，而HLAA31和CW4在非家族性白癜风患者中存在显著相关性。家族性和非家族性白癜风患者的临床特征和人类白细胞抗原表型的差异提示其发病过程具有异质性。
Of 131 patients with non-segmental vitiligo studied, 29 (22%) had a family history of this disorder. The clinical features and HLA antigens were assessed, and a comparison made between patients with familial and those with non-familial, non-segmental vitiligo. Familial patients developed skin lesions significantly earlier than non-familial patients. There was a significant association between HLA-B46 and familial non-segmental vitiligo, whereas HLA-A31 and CW4 were found in non-familial patients. The differences in clinical features and HLA phenotypes suggest heterogeneity in the pathogenic process between familial and non-familial vitiligo patients.