Renin-angiotensin system in osteoarthritis: A new potential therapy
Renin-angiotensin system in osteoarthritis: A new potential therapy
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骨关节炎中的肾素-血管紧张素系统：一种新的潜在疗法
DOI：
10.1016/j.intimp.2019.105796
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发表时间：
2019
影响因子：
5.6
通讯作者：
Zeng Yi
中科院分区：
文献类型：
--
作者：
Wu Yuangang;Lu Xiaoxi;Li Mingyang;Zeng Junfeng;Zeng Jun;Shen Bin;Zeng Yi
骨关节炎是最常见的慢性关节疾病之一。然而，其机制仍不清楚。传统的肾素-血管紧张素系统(RAS)是调节体内平衡和控制平衡的重要系统。近年来，RAS相关成分在骨性关节炎的发生中发挥了重要作用。本文的目的是总结与骨性关节炎相关的RAS相关成分的研究结果。本研究系统地检索了PubMed、Embase、Medline和Web of Science等电子医疗数据库。搜索目标包括描述RAS相关成分在骨性关节炎中的作用的英文出版物，包括肾素、血管紧张素转换酶(ACE)、血管紧张素II(Ang II)和血管紧张素受体(ATR)的作用。此外，本研究还总结了RAS相关成分干预骨性关节炎的可能途径。本研究发现RAS相关成分包括肾素、血管紧张素转换酶、血管紧张素Ⅱ、血管紧张素Ⅱ受体和血管紧张素Ⅱ受体参与了骨性关节炎的炎症和软骨细胞肥大。RAS参与信号转导通路，包括NF-κB、JNK、VEGFR/Tie-2和AxNA2/AxNA2R轴，可能成为治疗骨性关节炎的潜在靶点。虽然RAS在骨性关节炎领域的研究较少，但RAS相关成分的致病作用仍是骨性关节炎治疗中的一个重要课题，未来这方面的研究可能会有很大的进展。
Osteoarthritis (OA) is one of the most common chronic joint diseases. However, the mechanism remains unclear. The traditional renin-angiotensin system (RAS) is an important system for regulating homeostasis and controlling balance. In recent years, RAS-related components have played an important role in the occurrence of OA. The purpose of this review is to summarize the research results of RAS-related components that are associated with OA. This study systematically searched e-medical databases such as PubMed, Embase, Medline, and Web of Science. The search targets included English publications describing the effects of RAS-related components in OA, including the role of renin, angiotensin-converting enzyme (ACE), Angiotensin II (Ang II), and angiotensin receptor (ATR). Additionally, this study summarizes the potential pathways for RAS-related components to intervene in OA. This study found that RAS-related components including renin, ACE, Ang II, AT1R and AT2R are involved in inflammation and chondrocyte hypertrophy in OA. RAS is involved in signaling pathways including the NF-κB, JNK, VEGFR/Tie-2, and the Axna2/Axna2R axis ones, which may be potential targets for the treatment of OA. Although there are few studies on RAS in the field of OA, the pathogenic effect of RAS-related components is still an important topic in OA treatment, and great progress may be made in this aspect in future studies.