The Regulators of Human Endometrial Stromal Cell Decidualization.

The Regulators of Human Endometrial Stromal Cell Decidualization.
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人子宫内膜基质细胞蜕膜化的调控因子。

DOI:
10.3390/biom12091275
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发表时间:
2022-09-10
期刊:
影响因子:
5.5
通讯作者:
Okada, Hidetaka
Okada, Hidetaka
中科院分区:
生物学2区
文献类型:
--
作者:
Murata, Hiromi;Tanaka, Susumu;Okada, Hidetaka

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有几个因素对于子宫内膜中的着床和随后的胎盘形成是重要的,包括免疫、血管生成、细胞外基质、葡萄糖代谢、反应性氧化应激和激素。这些因素的参与或异常可损害典型蜕膜化。异常的蜕膜化可导致围产期并发症,如破坏滋养细胞的侵袭。人子宫内膜间质细胞(hESC)的形态和功能的急剧变化对于人子宫内膜的蜕膜化是重要的; hESC用于在体外诱导最佳形态和功能的蜕膜化,因为它们含有雌激素和孕激素受体。本文将重点介绍近年来有关人胚胎干细胞蜕膜化的研究进展,包括本实验室的研究结果。
Several factors are important for implantation and subsequent placentation in the endometrium, including immunity, angiogenesis, extracellular matrix, glucose metabolism, reactive oxidative stress, and hormones. The involvement or abnormality of these factors can impair canonical decidualization. Unusual decidualization can lead to perinatal complications, such as disruption of trophoblast invasion. Drastic changes in the morphology and function of human endometrial stromal cells (hESCs) are important for decidualization of the human endometrium; hESCs are used to induce optimal morphological and functional decidualization in vitro because they contain estrogen and progesterone receptors. In this review, we will focus on the studies that have been conducted on hESC decidualization, including the results from our laboratory.
DOI: 10.1038/nm.3012
发表时间: 2012-12
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影响因子: 82.9
作者:
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通过确定因子的混合物将外周血 NK 细胞转化为蜕膜 NK 样表型。
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