Corneal Densitometry, Central Corneal Thickness, and Corneal Central-to-Peripheral Thickness Ratio in Patients With Fuchs Endothelial Dystrophy
Corneal Densitometry, Central Corneal Thickness, and Corneal Central-to-Peripheral Thickness Ratio in Patients With Fuchs Endothelial Dystrophy
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DOI：
10.1097/ico.0000000000000711
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发表时间：
2016-03-01
期刊：
影响因子：
2.8
通讯作者：
Rosentreter, Andre
中科院分区：
文献类型：
--
作者：
Alnawaiseh, Maged;Zumhagen, Lars;Rosentreter, Andre
目的：对49例Fuchs内皮营养不良患者和51例健康对照的Fuchs内皮细胞营养不良(Fuchs Endothaldystrophy，FED)患者和51例健康对照的眼表和眼前段数据进行回顾性分析。患者使用基于Scheimpflug的Oculus Pentacam进行检查。结果：FED组角膜总厚度和总直径的背向散射值均显著高于对照组(FED组：28.8±/-6.7；对照组：24.3±/-4.1；P<；0.001)。当在全CT上将角膜表面划分为同心环区时，差异仅在两个中心环上有显著差异(P<；0.001)。角膜中央0.001~2 mm环的总CT背向散射值与中央角膜厚度呈中度正相关(P<；0.55)。结论：FED患者角膜中央后向散射值大于正常人。角膜密度测量使我们能够评估不同角膜层和不同环中的角膜的光学质量。这是一种有用的客观方法，结合中央角膜厚度和角膜中央/周围厚度比，可以帮助量化FED的严重程度。
Purpose:The aim of the study was to quantify Scheimpflug corneal densitometry in patients with Fuchs endothelial dystrophy (FED).Methods:In this study, we retrospectively reviewed the charts and anterior segment data of 49 patients with FED before posterior lamellar keratoplasty and 51 healthy controls. The patients were examined using the Scheimpflug-based Oculus Pentacam. Central corneal thickness (CCT), ring-averaged (on a circle of 2, 2.4-10 mm diameter) noncentral corneal thickness, and densitometry data in different corneal layers and in different annuli were extracted and analyzed.Results:The total corneal light backscatter at total corneal thickness (CT) and at total diameter was significantly higher in the FED group when compared with the control group (FED group: 28.8 +/- 6.7; control group: 24.3 +/- 4.1; P < 0.001). When the corneal surface was divided into concentric annular zones at total CT, the differences were significant only in the 2 central annuli (P < 0.001). The total corneal light backscatter at total CT in the central 0-2 mm annulus correlated moderately with the central corneal thickness (Pearson's correlation = 0.55, P < 0.001).Conclusions:Corneal light backscatter in the central cornea was greater in patients with FED than in normal subjects. Corneal densitometry enables us to evaluate the optical quality of the cornea in different corneal layers and in different annuli. It is a useful, objective method that, in combination with central corneal thickness and corneal central-to-peripheral thickness ratio, can help to quantify FED severity.