Towards an understanding of unique and shared pathways in the psychopathophysiology of ADHD
Towards an understanding of unique and shared pathways in the psychopathophysiology of ADHD
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DOI：
10.1111/j.1467-7687.2005.00400.x
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发表时间：
2005-03-01
影响因子：
3.7
通讯作者：
Taylor, E
中科院分区：
文献类型：
--
作者：
Banaschewski, T;Hollis, C;Taylor, E
大多数注意力缺陷多动障碍（ADHD）的研究都将病例与未受影响的对照组进行了比较。这导致了许多关联，但与其他疾病相比，它们对ADHD的特异性存在不确定性。我们提出了一个选择性的研究综述，比较多动症与其他疾病的神经心理学，神经生物学和遗传相关性。到目前为止，尚未确定具体的病理生理学途径。ADHD可能与执行功能缺陷无关。ADHD症状可能与动机异常、运动组织和时间感知更具体地相关，但尚未确定。最近的研究结果表明，ADHD和其他疾病的共同遗传责任提出了关于诊断界限的问题。在未来的研究中，ADHD的病理生理机制的描述需要将认知，成像和遗传技术与定义更同质的临床组的挑战相匹配;需要多站点合作项目。
Most attention deficit hyperactivity disorder (ADHD) research has compared cases with unaffected controls. This has led to many associations, but uncertainties about their specificity to ADHD in contrast with other disorders. We present a selective review of research, comparing ADHD with other disorders in neuropsychological, neurobiological and genetic correlates. So far, a specific pathophysiological pathway has not been identified. ADHD is probably not specifically associated with executive function deficits. It is possible, but not yet established, that ADHD symptoms may be more specifically associated with motivational abnormalities, motor organization and time perception. Recent findings indicating common genetic liabilities of ADHD and other conditions raise questions about diagnostic boundaries. In future research, the delineation of the pathophysiological mechanisms of ADHD needs to match cognitive, imaging and genetic techniques to the challenge of defining more homogenous clinical groups; multi-site collaborative projects are needed.