Low serum selenium concentrations are associated with poor grip strength among older women living in the community
Low serum selenium concentrations are associated with poor grip strength among older women living in the community
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DOI：
10.1002/biof.5520290104
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发表时间：
2007-01-01
期刊：
影响因子：
6
通讯作者：
Semba, Richard D.
中科院分区：
文献类型：
--
作者：
Beck, Justine;Ferrucci, Luigi;Semba, Richard D.
衰老与肌肉力量的丧失有关，而肌肉力量的丧失又与虚弱、残疾和死亡的风险增加有关。随着年龄的增长导致肌肉力量下降的因素还没有被很好地描述。硒对正常肌肉功能很重要，因为它在硒酶中起着保护肌肉免受氧化损伤的作用。我们假设低血清硒浓度与握力差有关。在马里兰州巴尔的摩市的妇女健康与老龄化研究I中，我们研究了676名中度至重度残疾社区妇女血清硒与握力之间的关系。在调整年龄、种族、体重指数、精神状态检查评分、吸烟史、高血压、充血性心力衰竭和抑郁等因素后，血清硒与握力相关（P = 0.04）。这项研究支持了硒对老年妇女肌肉力量很重要的观点。
Aging is associated with a loss of muscle strength, and, in turn, loss of muscle strength has been associated with increased risk of frailty, disability and mortality. The factors that contribute to loss of muscle strength with aging have not been well characterized. Selenium is important in normal muscle function because of its role in selenoenzymes that protect muscle against oxidative damage. We hypothesized that low serum selenium concentrations were associated with poor grip strength. We examined the association between serum selenium and hand grip strength among 676 moderately to severely disabled community-dwelling women in the Women's Health and Aging Study I in Baltimore, Maryland. After adjusting for age, race, body mass index, Mini-Mental Status Examination score, current smoking, hypertension, congestive heart failure and depression, serum selenium was associated with grip strength (P = 0.04). This study supports the idea that selenium is important to muscle strength in older women.