Clinical Characteristics and Outcomes of Rare Fungal Keratitis Caused by Verticillium dahliae
Clinical Characteristics and Outcomes of Rare Fungal Keratitis Caused by Verticillium dahliae
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大丽黄萎病引起的罕见真菌性角膜炎的临床特征和结局
DOI：
10.1007/s11046-021-00604-7
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发表时间：
2021-11
期刊：
影响因子：
5.5
通讯作者：
Xiaolin Qi
中科院分区：
文献类型：
--
作者：
Qing Huang;Wenlu Zhang;Yu Sun;Xiaofeng Li;Xiaoyu Zhang;Xiuhai Lu;Xiaolin Qi
目的观察大丽花黄萎病致真菌性角膜炎的临床特点及治疗效果。回顾性分析7例大丽花黄萎病引起真菌性角膜炎的临床资料。评估患者的临床表现、真菌学、体外抗真菌药敏、治疗方案及预后。7例患者均为农场工人，其中5例由植物外伤引起。角膜溃疡呈圆形，范围相对有限，直径主要在2 - 7mm之间。间质浸润轻微，无伪足、苔藓或内皮斑块。在角膜刮屑和共聚焦显微镜下检测到完整的菌丝，通过形态学和核糖体DNA内部转录间隔区测序鉴定分离株。体外抗真菌药敏试验显示，抗真菌药物对两性霉素b最敏感。6例溃疡小于角膜厚度2/3的患者，仅1只眼抗真菌治疗18天后溃疡愈合。其余5例患者行角膜溃疡清创或结膜瓣覆盖手术。其余1例溃疡深度大于角膜厚度2/3者行板层角膜移植术。由大丽花黄萎病引起的真菌性角膜炎具有典型的轻度炎症反应体征，对抗真菌药物不敏感。建议患者尽快进行角膜溃疡清创，促进溃疡快速愈合。
To observe clinical characteristics and treatment outcomes of fungal keratitis caused by Verticillium dahliae. Clinical data of 7 patients diagnosed as fungal keratitis cause by Verticillium dahliae were retrospectively analyzed. The clinical manifestations, mycology, in vitro antifungal susceptibility, treatment regimens and prognoses of the patients were evaluated. All 7 patients were farm worker, of which 5 cases were caused by plant trauma. The corneal ulcer had a round shape and a relatively limited range with the diameters mainly in the range of 2–7 mm. The stromal infiltration was mild, and had no pseudopodia, mossiness or endothelial plaques. Intact hyphaes were detected in corneal scrapings and confocal microscopy, isolates were identified by morphology and by sequencing the internal transcribed spacer region of ribosomal DNA. In vitro antifungal susceptibility testing showed that the most sensitive antifungal drug was Amphotericin B. In the 6 patients with an ulcer less than 2/3 of the corneal thickness, the ulcer healed after 18 days of antifungal treatment only in one eye. The other five patients underwent corneal ulcer debridement or conjunctival flap covering surgery. The remaining one patient with ulcer depth more than 2/3 of the corneal thickness underwent lamellar keratoplasty. Fungal keratitis caused by Verticillium dahliae has typical signs of a mild inflammatory response, and is not sensitive to antifungal drugs. It is recommended that patients undergo corneal ulcer debridement as soon as possible to promote rapid healing of the ulcers.
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影响因子：
4.2
作者：
Hsu HY;Ernst B;Schmidt EJ;Parihar R;Horwood C;Edelstein SL
通讯作者：
Edelstein SL
影响因子：
2
作者：
Sahay, Pranita;Goel, Siddhi;Titiyal, Jeewan S.
通讯作者：
Titiyal, Jeewan S.
DOI：
10.1136/bjophthalmol-2016-309656
发表时间：
2017-08
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
Chidambaram JD;Prajna NV;Larke N;Macleod D;Srikanthi P;Lanjewar S;Shah M;Lalitha P;Elakkiya S;Burton MJ
通讯作者：
Burton MJ
DOI：
10.3760/cma.j.cn112142-20191120-00586
发表时间：
2020-08
期刊：
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology
影响因子：
--
作者：
Z. Wei;Q. Liang
通讯作者：
Z. Wei;Q. Liang
角膜移植后复发性真菌性角膜炎的危险因素、临床特征和结果
影响因子：
13.7
作者：
Shi, Weiyun;Wang, Ting;Li, Huiping
通讯作者：
Li, Huiping