Distribution of myo-inositol in the cat cochlear nucleus.
Distribution of myo-inositol in the cat cochlear nucleus.
复制标题
猫耳蜗核中肌醇的分布。
DOI：
10.1111/j.1471-4159.1982.tb05333.x
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发表时间：
1982
影响因子：
4.7
通讯作者：
Sherman,WR
中科院分区：
文献类型：
--
作者：
Godfrey,DA;Hallcher,LM;Laird,MH;Matschinsky,FM;Sherman,WR
The distribution ofmyo‐inositol, a substance that has been implicated in synaptic transmission, has been mapped within sections of the cat cochlear nucleus as well as some nearby regions. Highest values in the cochlear nucleus were found in regions of granule cells along the periphery of the anteroventral subdivision of the nucleus. Highest values overall were found in the molecular layer of the cerebellar flocculus. A fairly good correlation was found betweenmyo‐inositol levels and activities of the enzymes of acetyl‐choline metabolism in the cat cochlear nucleus, supporting the possibility thatmyo‐inositol may be involved in cholinergic synaptic transmission. No positive correlation was found betweenmyo‐inositol levels and the levels of glutamate, aspartate, glycine, or γ‐aminobutyric acid (GABA). The most striking gradient ofmyo‐inositol levels within a region was found in the auditory nerve, where differentmyo‐inositol levels might be related to nerve fibers innervating different parts of the cochlea. The distribution ofscyllo‐inositol, a stereoisomer ofmyo‐inositol, was also examined, and found to parallel closely the distribution ofmyo‐inositol, with levels 4–5% as high.
