Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors
Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors
复制标题
DOI：
10.3390/nu11010028
复制
发表时间：
2019-01-01
期刊：
影响因子：
5.9
通讯作者：
Ryan, Elizabeth P.
中科院分区：
文献类型：
--
作者：
Baxter, Bridget A.;Oppel, Renee C.;Ryan, Elizabeth P.
结直肠癌（CRC）是美国癌症相关死亡的第三大原因，新的证据支持增加豆类（如海军豆）的消费可以降低风险。海军豆的消费以前被证明可以调节宿主和微生物组的代谢，进行这项研究是为了评估对人类粪便代谢组的影响，其中包括海军豆代谢物的存在。这项为期4周的随机对照试验，对超重和肥胖的CRC幸存者进行了研究，每天摄入1餐和1份零食。干预包括35 g煮熟的菜豆或大量营养素匹配的膳食和零食，对照组为0 g菜豆（n = 18）。与参与者的基线相比，在第28天食用海军豆的参与者的粪便中有30个统计学显著的代谢物差异（p
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States and emerging evidence supports that increased consumption of legumes, such as navy beans, can reduce risk. Navy bean consumption was previously shown to modulate host and microbiome metabolism, and this investigation was performed to assess the impact on the human stool metabolome, which includes the presence of navy bean metabolites. This 4-week, randomized-controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily. The intervention contained 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18). There were 30 statistically significant metabolite differences in the stool of participants that consumed navy bean at day 28 compared to the participants' baseline (p