CONE VISUAL PIGMENTS ARE PRESENT IN GECKO ROD CELLS
CONE VISUAL PIGMENTS ARE PRESENT IN GECKO ROD CELLS
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DOI：
10.1073/pnas.89.15.6841
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发表时间：
1992-08-01
影响因子：
11.1
通讯作者：
EBREY, TG
中科院分区：
文献类型：
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作者：
KOJIMA, D;OKANO, T;EBREY, TG
壁虎（Gekko gekko）是一种夜行性蜥蜴，有两种视觉色素，P467和P521。尽管感光细胞的纯杆形态，P521和P467的生化性质类似于碘视蛋白（鸡红敏感锥视色素）和视紫红质，分别。我们发现从cDNA推导的P521的氨基酸序列与碘视蛋白的氨基酸序列非常相似。此外，P467与鸡绿色敏感的视锥色素具有最高的同源性，尽管它与视紫红质也具有相对高的同源性。这些结果给予额外的力量嬗变理论的墙壁[墙壁，G。L.（1934）Am. J. Ophthalmol. 17，892-915]，他提出蜥蜴的杆状感光细胞来源于祖先的锥形感光细胞。显然，在进化过程中，视色素的氨基酸序列的变化比感光细胞的形态变化要小。
The Tokay gecko (Gekko gekko), a nocturnal lizard, has two kinds of visual pigments, P467 and P521. In spite of the pure-rod morphology of the photoreceptor cells, the biochemical properties of P521 and P467 resemble those of iodopsin (the chicken red-sensitive cone visual pigment) and rhodopsin, respectively. We have found that the amino acid sequence of P521 deduced from the cDNA was very similar to that of iodopsin. In addition, P467 has the highest homology with the chicken green-sensitive cone visual pigment, although it also has a relatively high homology with rhodopsins. These results give additional strength to the transmutation theory of Walls [Walls, G. L. (1934) Am. J. Ophthalmol. 17, 892-915], who proposed that the rod-shaped photoreceptor cells of lizards have been derived from ancestral cone-like photoreceptors. Apparently amino acid sequences of visual pigments are less changeable than the morphology of the photoreceptor cells in the course of evolution.