Blepharospasm: Past, present, and future
Blepharospasm: Past, present, and future
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DOI：
10.1097/00002341-199809000-00002
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发表时间：
1998-09-01
影响因子：
2
通讯作者：
Jordan, DR
中科院分区：
文献类型：
--
作者：
Anderson, RL;Patel, BCK;Jordan, DR
为了调查眼睑痉挛的原因、相关性和治疗结果，通过广泛的问卷调查对1，653例患者进行了评估，以研究眼睑痉挛和采用全肌切除术、肉毒杆菌毒素、药物治疗以及良性原发性眼睑痉挛研究基金会（BEBRF）的帮助进行治疗的长期结果。BEBRF治疗后好转率为90%，全肌切除术后好转率为88%，A型肉毒毒素治疗后好转率为86%，药物治疗后好转率为43%。患者接受BEBRF的比例为96%，全肌切除术为82%，A型肉毒杆菌毒素为95%，药物治疗为57%。眼睑痉挛的起源和表现是多因素的。一个恶性循环和缺陷电路理论来解释起源和直接治疗，而不是一个有缺陷的具体位点。所有四种形式的治疗评估是有用的，必须根据病人的需要。Mattie Lou Koster和BEBRF对眼睑痉挛患者的帮助比任何其他方式都要多，所有患者都应该被告知这个支持小组。全肌切除术是肉毒杆菌毒素治疗失败的保留方法，而有限的肌切除术是肉毒杆菌毒素治疗的一个很好的辅助方法。
To investigate causes, associations, and results of treatment with blepharospasm, 1,653 patients were evaluated by extensive questionnaires to study blepharospasm and long-term results of treatment with the full myectomy operation, botulinum-A toxin, drug therapy, and help from the Benign Essential Blepharospasm Research Foundation (BEBRF). The percent of patients improved by the BEBRF was 90%, full myectomy 88%, botulinum-A toxin 86%, and drug therapy 43%. The patient acceptance rate for the BEBRF was 96%, full myectomy 82%, botulinum-A toxin 95%, and drug therapy 57%. Blepharospasm is multifactorial in origin and manifestation. A vicious cycle and defective circuit theory to explain origin and direct treatment rather than a defective specific locus is presented. All four forms of therapy evaluated are useful and must be tailored to the patient's needs. Mattie Lou Koster and the BEBRF have helped blepharospasm sufferers more than any other modality, and all patients should be informed of this support group. The full myectomy is reserved for botulinum-a toxin failures, and the limited myectomy is an excellent adjunct to botulinum-A toxin.