An autonomous and controllable light-driven DNA walking device.
An autonomous and controllable light-driven DNA walking device.
复制标题
DOI：
10.1002/anie.201107733
复制
发表时间：
2012-03-05
影响因子：
16.6
通讯作者：
Tan, Weihong
中科院分区：
文献类型：
--
作者：
You, Mingxu;Chen, Yan;Zhang, Xiaobing;Liu, Haipeng;Wang, Ruowen;Wang, Kelong;Williams, Kathryn R;Tan, Weihong
纳米技术的发展在很大程度上受到了生物世界的启发。这个复杂但组织良好的生命系统拥有一系列分子大小的机器，负责信息处理，结构构建，有时还负责运动。我们在这里提出了一种新的光动力DNA机械装置，这让人想起自然界中的细胞蛋白马达，特别是那些绿色植物。这种基于芘辅助的二硫键光解的行走装置能够自主运动，并具有光控制的起始、终止和速度。基于DNA序列设计和温度、离子强度等物理条件，这种以光子为燃料的DNA步行者表现出的操作自由度和机械速度在未来可能与蛋白质马达相媲美。
The development of nanotechnology has been largely inspired by the biological world. The complex, but well-organized, living system hosts an array of molecular-sized machines responsible for information processing, structure building and, sometimes, movement. We present here a novel light-powered DNA mechanical device, which is reminiscent of cellular protein motors in nature, especially those of green plants. This walking device, which is based on pyrene- assisted photolysis of disulfide bonds, is capable of autonomous locomotion, with light control of initiation, termination and velocity. Based on DNA sequence design and such physical conditions as temperature and ionic strength, this photon-fueled DNA walker exhibits the type of operational freedom and mechanical speed that may rival protein motors in the future.