Voxel-based morphometry reveals regional reductions of gray matter volume in school-aged children with short-term type 1 diabetes mellitus
Voxel-based morphometry reveals regional reductions of gray matter volume in school-aged children with short-term type 1 diabetes mellitus
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DOI：
10.1097/wnr.0000000000001238
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发表时间：
2019-05-01
期刊：
影响因子：
1.7
通讯作者：
Lin, Xiangtao
中科院分区：
文献类型：
--
作者：
Liu, Kun;Huang, Xiaoyan;Lin, Xiangtao
1型糖尿病（T1DM）患儿由于可能对大脑造成损伤，需要进行随访观察。然而，短期T1DM对学龄儿童灰质的影响尚不清楚。本研究旨在评估学龄儿童短期T1DM的灰质体积（GMV）变化及其与临床变量的关系。21名学龄T1DM儿童与21名性别和年龄相匹配的对照患者进行比较。使用3.0-Tesla扫描仪进行t1加权梯度回波三维MRI，并使用FSL软件对所得图像进行处理，以评估两组之间GMV的差异。T1DM患儿表现为左侧颞中回（LMTG）、右侧中央后回和左侧额下回三角区（LTP-FIG） GMV下降。T1DM组和对照组之间的智商（IQ）没有显著变化。在T1DM患者中，LMTG的GMV与全面智商或语言智商之间存在显著的正相关。此外，糖化血红蛋白水平升高与T1DM组LMTG和LTP-FIG的GMV降低呈负相关。这些发现表明，短期T1DM可能导致学龄儿童的区域性结构性脑缺陷。LMTG的GMV可能影响智商，近期血糖控制不良可能对T1DM儿童LMTG和LTP-FIG的GMV产生不利影响。版权所有(c) 2019威科集团健康有限公司版权所有。
Follow-up observation is needed for type 1 diabetes mellitus (T1DM) children due to the potential injury to the brain. However, the effect of short-term T1DM on gray matter in school-aged children is still unclear. This study aimed to evaluate gray matter volume (GMV) changes and their relationships with clinical variables in school-aged children with short-term T1DM. Twenty-one school-aged T1DM children were compared with 21 control patients, matched for sex and age. T1-weighted gradient echo threedimensional MRI was performed using a 3.0-Tesla scanner and the resulting images were processed with FSL software to assess the difference in GMV between the two groups. The children with T1DM presented with decreased GMV in the left middle temporal gyrus (LMTG), the right postcentral gyrus, and the left triangular part of the frontal inferior gyrus (LTP-FIG). No significant changes in intelligence quotient (IQ) were found between the T1DM and control groups. In T1DM patients, there was a significant positive correlation between the GMV of LMTG and full-scale IQ or linguistic IQ. In addition, an increased glycosylated hemoglobin level was negatively correlated with reduced GMV in the LMTG and LTP-FIG in the T1DM group. These findings suggest that short-term T1DM could lead to regional structural brain deficits in school-aged children. The GMV of the LMTG may affect IQ, and poor recent glycemic control may have an adverse effect on GMV in the LMTG and LTP-FIG in T1DM children. Copyright (c) 2019 Wolters Kluwer Health, Inc. All rights reserved.