Modifying factors in urinary bladder carcinogenesis
Modifying factors in urinary bladder carcinogenesis
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膀胱癌发生的改变因素
DOI：
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发表时间：
1983
影响因子：
10.4
通讯作者：
K. Imaida
中科院分区：
文献类型：
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作者：
N. Ito;S. Fukushima;T. Shirai;K. Nakanishi;R. Hasegawa;K. Imaida
N-丁基-N-（4-羟丁基）亚硝胺（BBN）是动物膀胱中的一种强致癌物。膀胱癌的BBN模型是人类膀胱癌的极好模型，并且已经导致对其发病机制的更多了解。在我们的研究中，BBN膀胱癌的组织发生和形态学特征进行了分析，在不同的动物物种，如大鼠，小鼠，仓鼠和豚鼠，也在不同的大鼠品系。乳头状或结节性增生（PN增生）是大鼠膀胱癌的癌前病变。因此，通过测量大鼠PN增生来判断各种化学物质在两阶段膀胱癌发生中的促进和抑制作用。膀胱促进剂糖精在大鼠中诱导PN增生的剂量依赖性和器官特异性效应在BBN启动后显示。强力启动后，在大鼠膀胱中可以更清楚地看到糖精的促进作用。还显示了膀胱对启动子的敏感性的菌株差异。这些结果提示，上述各种因素对人膀胱癌的发生也可能具有调节作用。
N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN) is a potent carcinogen in the urinary bladder of animals. The BBN model of bladder cancer is an excellent model of human urinary bladder cancer and has already led to a greater knowledge of its pathogenesis. In our studies, histogenesis and morphological characteristics of BBN urinary bladder cancer were analyzed in different animal species such as rats, mice, hamsters and guinea pigs and also in different rat strains. Papillary or nodular hyperplasia (PN hyperplasia) is found to be a preneoplastic lesion of the rat urinary bladder. Therefore, the promoting and inhibitory effects of various chemicals in two-stage urinary bladder carcinogenesis were judged by measuring PN hyperplasia in rats. Dose-dependent and organ-specific effects of the urinary bladder promoter, saccharin, in the induction of PN hyperplasia were shown in rats after initiation by BBN. The promoting effect of saccharin was seen more clearly in the urinary bladder of rats after potent initiation. A strain difference in susceptibility of the urinary bladder to the promoter was also shown. These results suggest that the above various factors may also have modifying activities on urinary bladder carcinogenesis in man.