Thyroid hormone signaling and deiodinase actions in muscle stem/progenitor cells
Thyroid hormone signaling and deiodinase actions in muscle stem/progenitor cells
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DOI：
10.1016/j.mce.2017.06.014
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发表时间：
2017-12-25
影响因子：
4.1
通讯作者：
Salvatore, Domenico
中科院分区：
文献类型：
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作者：
Ambrosio, Raffaele;De Stefano, Maria Angela;Salvatore, Domenico
甲状腺激素（TH）调节几乎所有脊椎动物组织的正常生长、发育和代谢等重要的生物功能。在骨骼肌中，TH 在调节卫星细胞（真正的骨骼肌干细胞）的功能中发挥着关键作用。已发现脱碘酶（D2 和 D3）可调节卫星细胞中各种 TH 靶基因的表达。脱碘酶表达和活性的调节构成了细胞自主的前受体机制，控制着肌生成各个阶段的关键步骤。在这里，我们回顾了脱碘酶在骨骼肌干细胞中的作用，特别是在肌肉稳态和再生中的作用。我们重点关注 T3 在干细胞功能和谱系进展中的作用。我们还讨论了如何在治疗上利用脱碘酶来改善骨骼肌疾病或损伤中卫星细胞介导的肌肉修复。 (C) 2017 年由爱思唯尔爱尔兰有限公司出版。
Thyroid hormone (TH) regulates such crucial biological functions as normal growth, development and metabolism of nearly all vertebrate tissues. In skeletal muscle, TH plays a critical role in regulating the function of satellite cells, the bona fide skeletal muscle stem cells. Deiodinases (D2 and D3) have been found to modulate the expression of various TH target genes in satellite cells. Regulation of the expression and activity of the deiodinases constitutes a cell-autonomous, pre-receptor mechanism that controls crucial steps during the various phases of myogenesis. Here, we review the roles of deiodinases in skeletal muscle stem cells, particularly in muscle homeostasis and upon regeneration. We focus on the role of T3 in stem cell functions and in commitment towards lineage progression. We also discuss how deiodinases might be therapeutically exploited to improve satellite-cell-mediated muscle repair in skeletal muscle disorders or injury. (C) 2017 Published by Elsevier Ireland Ltd.