Hyperglycemia and the rate of lactic acid accumulation during cerebral ischemia in developing animals: in vivo proton MRS study.
Hyperglycemia and the rate of lactic acid accumulation during cerebral ischemia in developing animals: in vivo proton MRS study.
复制标题
DOI：
10.1159/000243749
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
R. S. Young;O. A. Petroff;W. Aquila;A. Cheung;J. Gore
中科院分区：
文献类型：
--
作者：
R. S. Young;O. A. Petroff;W. Aquila;A. Cheung;J. Gore
在脑缺血期间，高血糖症对成人脑有有害影响，但对新生儿脑无影响。这种现象可能与以下事实有关，即在遭受脑缺血的成年动物中，高血糖使乳酸的缺血性蓄积增加多达10倍。本研究的目的是确定脑缺血期间的高血糖是否在发育中的动物中产生类似的乳酸积累速率增加。在体质子磁共振波谱实验的数据表明，血糖浓度不影响乳酸积累的速度在脑缺血期间无论是在新生狗或幼年兔。在发育中的动物中，在高血糖期间乳酸积累的缺血速率没有增加，这与血糖浓度对成年动物中乳酸积累速率的显著影响形成鲜明对比。乳酸形成总量和积累速率的差异可能部分导致幼年动物对脑缺血的更大耐受性。
During cerebral ischemia, hyperglycemia has a deleterious effect upon the adult brain but not the neonatal brain. This phenomenon may be related to the fact that hyperglycemia in adult animals subjected to cerebral ischemia raises the ischemic accumulation of lactate by as much as 10-fold. The purpose of this study was to determine whether hyperglycemia during cerebral ischemia produces a similar increase in the rate of lactic acid accumulation in developing animals. Data from in vivo proton magnetic resonance spectroscopic experiments showed that blood glucose concentration did not affect the rate of lactic acid accumulation during cerebral ischemia in either the neonatal dog or juvenile rabbit. The lack of increase in the ischemic rate of lactic acid accumulation during hyperglycemia in the developing animal contrasts sharply with the marked effect of blood glucose concentration upon the rate of lactic acid accumulation in the adult animal. Differences in the total amount of lactic acid formed and the rate at which it is accumulated may contribute, in part, to the greater tolerance of the young animal to cerebral ischemia.