Gut microbes and Drosophila behavior
Gut microbes and Drosophila behavior
复制标题
肠道微生物和果蝇行为
DOI：
10.1007/978-1-0716-2321-3_5
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Kuraishi T
中科院分区：
文献类型：
--
作者：
Kadoguchi H;Hori A;Kuraishi T
肠道微生物群在肠道-大脑相互作用中起着重要作用。从昆虫到哺乳动物，使用无菌动物的研究表明，本土宿主微生物会影响情绪活动、压力和性行为。此外，微生物似乎控制人类精神疾病，如自闭症和抑郁症。肠道细菌感染也会影响宿主的行为。例如，食物中毒会导致食物摄入行为的停止。有趣的是，肠道寄生虫通过操纵宿主行为来促进其传播。然而，肠道微生物如何调节大脑功能的潜在机制仍有待阐明，果蝇是神经生物学，特别是本能行为的遗传解剖的有效动物模型。在这里，我们为对微生物学感兴趣的果蝇神经生物学家提供了详细的肠道细菌（内源性和感染性）研究方法。
Gut microbiota plays an essential role in gut–brain interactions. From insect to mammals, studies using germ-free animals have demonstrated that indigenous host microbes influence emotional activities, stress, and sexual behaviors. In addition, microbes appear to govern human mental disorders such as autism and depression. Bacterial infections of the gut also influence host behaviors. For example, food poisoning causes the cessation of food intake behavior. Interestingly, intestinal parasites facilitate their transmission by manipulating host behaviors. However, the underlying mechanisms of how gut microbes modulate brain functions remain to be elucidated.Drosophila melanogasteris an effective animal model in neurobiology, particularly the genetic dissection of instinctive behaviors. Here, we provide detailed methods of working with gut bacteria—endogenous as well as infectious—forDrosophilaneurobiologists who are interested in microbiology.