CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches
CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches
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DOI：
10.1016/j.immuni.2006.02.015
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发表时间：
2006-05-01
期刊：
影响因子：
32.4
通讯作者：
McSorley, Stephen J.
中科院分区：
文献类型：
--
作者：
Salazar-Gonzalez, Rosa Maria;Niess, Jan H.;McSorley, Stephen J.
树突状细胞（DC）激活T细胞对于启动适应性免疫应答和抵抗病原体的保护至关重要。在这里，我们证明了派伊尔集合淋巴结（PP）中的一个专门的DC亚群介导了病原体特异性T细胞的快速激活。该DC亚群的特征在于表达趋化因子受体CCR6，并且仅在PP中发现。CCR6（+）DC在肠道病原体侵袭滤泡相关上皮（FAE）时被募集到PP的圆顶区域，并负责病原体特异性T细胞的快速局部活化。CCR6缺陷的DC不能响应PP的细菌入侵，并且不能启动T细胞活化，导致对口腔感染的防御降低。因此，DC的CCR6依赖性调节负责针对肠侵入性病原体的局部T细胞依赖性防御。
T cell activation by dendritic cells (DCs) is critical to the initiation of adaptive immune responses and protection against pathogens. Here, we demonstrate that a specialized DC subset in Peyer's patches (PPs) mediates the rapid activation of pathogen specific T cells. This DC subset is characterized by the expression of the chemokine receptor CCR6 and is found only in PPs. CCR6(+) DCs were recruited into the dome regions of PPs upon invasion of the follicle associated epithelium (FAE) by an enteric pathogen and were responsible for the rapid local activation of pathogen-specific T cells. CCR6-deficient DCs were unable to respond to bacterial invasion of PPs and failed to initiate T cell activation, resulting in reduced defense against oral infection. Thus, CCR6-dependent regulation of DCs is responsible for localized T cell dependent defense against entero-invasive pathogens.