EFFECT OF RESTRAINT ON GASTRIC ACIDITY IN RAT
EFFECT OF RESTRAINT ON GASTRIC ACIDITY IN RAT
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DOI：
10.1152/ajplegacy.1962.202.4.812
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发表时间：
1962-01-01
影响因子：
--
通讯作者：
MORENO, OM
中科院分区：
文献类型：
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作者：
BRODIE, DA;MARSHALL, RW;MORENO, OM
通过在雄性Holtzman大鼠的胃瘤胃部分植入不锈钢插管来制备慢性胃瘘大鼠，并在无约束和约束状态下收集胃内容物。同时研究了急性幽门结扎大鼠不受限制和限制时的胃分泌情况。在最初的 4 小时收集期间，与幽门结扎大鼠相比，慢性瘘大鼠的胃内容物体积、游离酸和总酸度以及游离酸输出显着较低。一项对慢性瘘管大鼠24小时胃内容物的研究表明，与对照值相比，束缚导致胃容量显着减少，游离酸和总酸浓度显着增加，游离酸排出量没有变化，而幽门结扎大鼠的胃容量显着减少，游离酸或总酸浓度没有变化，游离酸排出量显着减少。这表明酸浓度的增加是束缚应激引起的胃分泌的重要变化。
Chronic gastric fistula rats were prepared by implanting stainless steel cannulas in the rumen portion of the stomachs of male Holtzman rats and gastric content was collected in both the unrestrained and restrained state. Gastric secretion in acute pylorus-ligated rats, unrestrained and restrained, was studied at the same time. Volume of gastric content, free and total acidity, and free acid output were significantly lower in the chronic fistula rats as compared to the pylorus-ligated rats in the initial 4-hr collection period. A study of 24-hr gastric content in chronic fistula rats showed that restraint produced a significant decrease in volume, a significant increase in free and total acid concentration, and no change in free acid output, while the restrained pylorusligated rats had a significant decrease in volume, no change in free or total acid concentration, and a significant decrease in free acid output as compared with control values. This suggests that an increase in acid concentration is an important change produced in gastric secretion by restraint stress.