The Function of Intragenic DNA Methylation: Insights from Insect Epigenomes
The Function of Intragenic DNA Methylation: Insights from Insect Epigenomes
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DOI：
10.1093/icb/ict003
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发表时间：
2013-08-01
影响因子：
2.6
通讯作者：
Goodisman, Michael A. D.
中科院分区：
文献类型：
--
作者：
Hunt, Brendan G.;Glastad, Karl M.;Goodisman, Michael A. D.
表观遗传在调节基因调控和表型可塑性方面起着重要的作用。特别是DNA甲基化，一直是许多旨在了解昆虫表观遗传信息功能的研究的焦点。然而，理解DNA甲基化需要了解其与其他表观遗传修饰的关系。在这里，我们回顾了最近的见解在昆虫基因组中的DNA甲基化的本地化，并进一步讨论这些见解的背景下，更大的真核表观基因组的功能意义。特别是，我们强调真核表观遗传景观的互补性。我们关注DNA甲基化对核小体稳定性的重要性，这可能解释DNA甲基化与基因表达的上下文依赖性关联。最后，我们认为，整合不同的表观遗传修饰的昆虫研究将大大推进我们的理解的表观遗传系统的进化和表观遗传的贡献发育调控。
Epigenetic inheritance plays a fundamentally important role in mediating gene regulation and phenotypic plasticity. DNA methylation, in particular, has been the focus of many recent studies aimed at understanding the function of epigenetic information in insects. An understanding of DNA methylation, however, requires knowledge of its context in relation to other epigenetic modifications. Here, we review recent insights into the localization of DNA methylation in insect genomes and further discuss the functional significance of these insights in the context of the greater eukaryotic epigenome. In particular, we highlight the complementarity of the eukaryotic epigenetic landscape. We focus on the importance of DNA methylation to nucleosome stability, which may explain the context-dependent associations of DNA methylation with gene expression. Ultimately, we suggest that the integration of diverse epigenetic modifications in studies of insects will greatly advance our understanding of the evolution of epigenetic systems and epigenetic contributions to developmental regulation.