Role of a transcription factor Pax6 in the developing vertebrate olfactory system
Role of a transcription factor Pax6 in the developing vertebrate olfactory system
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DOI：
10.1111/j.1440-169x.2007.00965.x
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发表时间：
2007-10
期刊：
影响因子：
4.6
通讯作者：
T. Nomura;Hasumi Haba;N. Osumi
中科院分区：
文献类型：
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作者：
T. Nomura;Hasumi Haba;N. Osumi
嗅觉系统负责捕捉和处理气味信息，这对动物的各种行为产生了重大影响。脊椎动物嗅觉系统由多个神经元组成，包括嗅上皮、嗅球和嗅皮质，这些神经元起源于不同的胚胎组织。转录因子Pax6在胚胎和出生后的嗅觉系统中强烈表达，并调节神经元的指定、迁移和分化。在这里，我们回顾了Pax6在嗅觉发育系统中的作用的经典和最新研究，并强调了脊椎动物嗅觉系统高度协调发育过程的细胞和分子机制。
The olfactory system is responsible for capturing and processing odorant information, which significantly influences a variety of behaviors in animals. The vertebrate olfactory system consists of several neuronal components including the olfactory epithelium, olfactory bulb and olfactory cortex, which originate from distinct embryonic tissues. The transcription factor Pax6 is strongly expressed in the embryonic and postnatal olfactory systems, and regulates neuronal specification, migration and differentiation. Here we review classical and recent studies focusing on the role of Pax6 in the developing olfactory system, and highlight the cellular and molecular mechanisms underlying the highly coordinated developmental processes of the vertebrate olfactory system.