Changes of brain activation pre- post short-term psychodynamic inpatient psychotherapy: An fMRI study of panic disorder patients
Changes of brain activation pre- post short-term psychodynamic inpatient psychotherapy: An fMRI study of panic disorder patients
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DOI：
10.1016/j.pscychresns.2010.06.005
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发表时间：
2010-11-30
影响因子：
2.3
通讯作者：
Dietrich, Sylvia
中科院分区：
文献类型：
--
作者：
Beutel, Manfred E.;Stark, Rudolf;Dietrich, Sylvia
认知行为干预已被证明可以改变大脑功能。我们使用情感语言go/nogo功能磁共振成像（fMRI）设计，以确定短期精神动力学住院治疗后惊恐障碍（PD）患者的大脑激活模式的变化。9名PD患者在治疗前后进行了fMRI检查; 18名健康对照者在相同的时间间隔（4周）进行了两次扫描。在go/nogo设计中，将对特定于恐慌的消极词的反应与语言匹配的积极和中性词进行比较。根据假设，患者比对照组更强烈地评价情感词，并选择性地回忆消极与积极/中性词。在治疗前，高边缘（海马和杏仁核）激活伴随着低前额叶激活消极的话。抑制相关的激活模式表明在情绪背景下的行为调节的困难在治疗结束时，恐慌相关的症状有显着改善，额边缘激活模式正常化。我们的研究结果表明，短期的心理动力学治疗导致额边缘电路的变化与以前的认知行为治疗结果没有什么不同。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Cognitive-behavioural interventions have been shown to change brain functioning. We used an emotional linguistic go/nogo functional magnetic resonance imaging (fMRI) design to determine changes of brain activation patterns of panic disorder (PD) patients following short-term psychodynamic inpatient treatment. Nine PD patients underwent fMRI before and after treatment; 18 healthy controls were scanned twice at the same interval (4 weeks). In the go/nogo design, responses to panic-specific negative words were compared with linguistically matched positive and neutral words. According to hypotheses, patients rated affective words more strongly than controls and selectively recalled negative vs. positive/neutral words. Before treatment, high limbic (hippocampus and amygdala) activation was accompanied by low prefrontal activation to negative words. Inhibition-related activation patterns indicated difficulties of behavioural regulation in emotional context At treatment termination, panic-related symptoms had improved significantly, and fronto-limbic activation patterns were normalized. Our results indicate that short-term psychodynamic treatment leads to changes in fronto-limbic circuitry not dissimilar to previous findings on cognitive-behavioural treatments. (C) 2010 Elsevier Ireland Ltd. All rights reserved.