Contrast Enhancement of the Anterior Eye Segment and Subarachnoid Space: Detection in the Normal State by Heavily T2-weighted 3D FLAIR
Contrast Enhancement of the Anterior Eye Segment and Subarachnoid Space: Detection in the Normal State by Heavily T2-weighted 3D FLAIR
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DOI：
10.2463/mrms.10.193
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发表时间：
2011-01-01
影响因子：
3
通讯作者：
Nakashima, Tsutomu
中科院分区：
文献类型：
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作者：
Naganawa, Shinji;Yamazaki, Masahiro;Nakashima, Tsutomu
目的：液体衰减反转恢复成像(FLAIR)在检测液体中低浓度的Gd基对比剂(GBCM)方面比T1加权图像更敏感，而重T2加权(HT(2)W)三维(3D)FLAIR图像最近被报道甚至比传统的3D FLAIR更敏感。方法：对10例疑似梅尼埃病患者静脉注射GBCM 4h后，在HT(2)W 3D FLAIR图像上观察眼前节(AES)、蛛网膜下腔(SAS)不同部位的高信号及脑池、脑室内脑脊液(CSF)的高信号。方法：10例疑似梅尼埃病的患者静脉注射GBCM 4h后，行HT(2)W 3D FLAIR检查。我们通过与5例患者的平扫图像比较，评估了AES、视神经周围的SAS、Meckel‘s Caves的SAS、内耳道的CSF、桥前池的CSF、侧脑室和第四脑室的CSF以及耳蜗液的信号强度。结果：增强前后脑桥实质图像的信号强度无明显差异。结论：静脉注射后4h，HT(2)W 3D FLAIR可在不同的含液间隙，如AES、各种SAS和CSF间隙中检出GBCM。
Purpose: Fluid-attenuated inversion recovery (FLAIR) has been reported more sensitive than T-1-weighted images in detecting low concentration gadolinium-based contrast media (GBCM) in fluid, and heavily T-2-weighted (hT(2)W) 3-dimensional (3D) FLAIR has recently been reported even more sensitive than conventional 3D FLAIR. We investigated whether high signal of the anterior eye segment (AES) and subarachnoid space (SAS) in various locations as well as cerebrospinal fluid (CSF) in cisterns and ventricles can be detected on hT(2)W 3D FLAIR images obtained 4 hours after intravenous administration of GBCM in subjects without eye and SAS diseases.Methods: Ten patients suspected of having Meniere's disease underwent hT(2)W 3D FLAIR 4 hours after intravenous administration of single-dose GBCM to evaluate endolymphatic hydrops. We evaluated signal intensity of AES, SAS surrounding the optic nerve, SAS in Meckel's cave, CSF in the internal auditory canal, CSF in the prepontine cistern, CSF in the lateral and fourth ventricles, and lymph fluid in the cochlea by comparison with non-contrast images obtained in a separate group of 5 patients. The signal intensity of each structure was normalized by that of the pontine parenchyma.Results: We observed no signal difference in images of the pontine parenchyma obtained before and after enhancement. Significant signal difference was seen in all structures except the lateral and fourth ventricles.Conclusion: Four hours after intravenous injection, GBCM can be detected by hT(2)W 3D FLAIR in various fluid-containing spaces, such as the AES and various SAS and CSF spaces.