Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort.
Vitamin K Status and Cognitive Function in Adults with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort.
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DOI：
10.1093/cdn/nzac111
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发表时间：
2022-08
影响因子：
4.8
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中科院分区：
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维生素 K 与认知功能有关，但对患有慢性肾病 (CKD) 的个体（存在维生素 K 不足和认知障碍风险）的研究尚缺乏。在 ≥ 55 岁的 CKD 成人中评估了维生素 K 状态生物标志物与认知能力的横断面关联（N = 714，49% 女性，44% 黑人）。主要结果是通过对各个测试的 z 分数进行平均计算得出的认知表现测试组的综合分数。使用血浆叶绿醌和去磷酸未羧基化基质 Gla 蛋白 [(dp)ucMGP] 测量维生素 K 状态。根据综合结果 (P = 0.03)，血浆 (dp)ucMGP 较低的参与者反映了较高的维生素 K 状态，其认知表现优于两个较高 (dp)ucMGP 类别的参与者 (P = 0.03)，而根据血浆叶绿醌类别，认知表现没有显着差异 (P = 0.08)。这两种生物标志物与单项测试的表现均不显着相关（所有 P > 0.05）。维生素 K 对 CKD 成人认知能力的重要性仍有待阐明。
Vitamin K is linked to cognitive function, but studies in individuals with chronic kidney disease (CKD), who are at risk for vitamin K insufficiency and cognitive impairment, are lacking. The cross-sectional association of vitamin K status biomarkers with cognitive performance was evaluated in ≥55-y-old adults with CKD (N = 714, 49% female, 44% black). A composite score of a cognitive performance test battery, calculated by averaging the z scores of the individual tests, was the primary outcome. Vitamin K status was measured using plasma phylloquinone and dephospho-uncarboxylated matrix Gla protein [(dp)ucMGP]. Participants with low plasma (dp)ucMGP, reflecting higher vitamin K status, had better cognitive performance than those in the two higher (dp)ucMGP categories based on the composite outcome (P = 0.03), whereas it did not significantly differ according to plasma phylloquinone categories (P = 0.08). Neither biomarker was significantly associated with performance on individual tests (all P > 0.05). The importance of vitamin K to cognitive performance in adults with CKD remains to be clarified.