IDENTIFICATION OF HEPATITIS-A VIRUS AS A TRIGGER FOR AUTOIMMUNE CHRONIC HEPATITIS TYPE-1 IN SUSCEPTIBLE INDIVIDUALS
IDENTIFICATION OF HEPATITIS-A VIRUS AS A TRIGGER FOR AUTOIMMUNE CHRONIC HEPATITIS TYPE-1 IN SUSCEPTIBLE INDIVIDUALS
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DOI：
10.1016/0140-6736(91)92858-y
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发表时间：
1991-05-18
期刊：
影响因子：
168.9
通讯作者：
BASSETTI, D
中科院分区：
文献类型：
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作者：
VENTO, S;GAROFANO, T;BASSETTI, D
为了确定自身免疫性慢性活动性肝炎（CAH）发病机制的相关因素，我们对13例自身免疫性慢性活动性肝炎患者的健康亲属进行了为期4年的前瞻性随访。每2个月监测58名亲属的各种血清学指标和t淋巴细胞迁移抑制活性。研究期间共发生亚临床急性甲型肝炎3例。在3名受试者中，有2名在感染甲型肝炎病毒（HAV）之前，抑制诱导剂T淋巴细胞特异性地控制对asialal糖蛋白受体（一种在肝细胞表面表达的抗原）的免疫应答。在这2名受试者中，特异性辅助性T细胞和asialal糖蛋白受体抗体在急性甲型肝炎后持续存在并增加，自身免疫性CAH 1型在5个月内出现。因此，在易感个体中，HAV是自身免疫性CAH的触发因素。
To identify factors contributing to the pathogenesis of autoimmune chronic active hepatitis (CAH) healthy relatives of 13 patients with the disorder were followed prospectively for 4 years. 58 relatives were monitored for various serological markers and for T-lymphocyte migration inhibitory activity every 2 months. 3 cases of subclinical acute hepatitis A occurred during the study. In 2 of the 3 subjects, before hepatitis A virus (HAV) infection, there was a defect in suppressor-inducer T lymphocytes specifically controlling immune responses to the asialoglycoprotein receptor, an antigen expressed on the hepatocyte surface. In these 2 subjects, specific helper T cells and antibodies to the asialoglycoprotein receptor persisted and increased after acute hepatitis A, and autoimmune CAH type 1 developed within 5 months. Thus, in susceptible individuals HAV is a trigger for autoimmune CAH.