AIE-active metal-organic frameworks: facile preparation, tunable light emission, ultrasensitive sensing of copper(ii) and visual fluorescence detection of glucose
AIE-active metal-organic frameworks: facile preparation, tunable light emission, ultrasensitive sensing of copper(ii) and visual fluorescence detection of glucose
复制标题
AIE 活性金属有机框架：易于制备、可调谐光发射、铜 (ii) 的超灵敏传感和葡萄糖的视觉荧光检测
DOI：
10.1039/d0tc00106f
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发表时间：
2020
影响因子：
6.4
通讯作者：
Chen Xiaoqing
中科院分区：
文献类型：
--
作者：
Xie Siqi;Liu Qi;Zhu Fawei;Chen Miao;Wang Lumin;Xiong Yu;Zhu Yuqiu;Zheng Yu;Chen Xiaoqing
通过将聚集致发光材料（AIEgens）与纳米级ZIF-8结合，制备了一系列具有良好光稳定性和优异分散性的新型发光金属有机骨架（LMOFs）。所开发的AIE活性mof不仅继承了AIEgens的AIE特性，包括激发态分子内质子转移（ESIPT）特性、强固态发光和大Stokes位移（115-202 nm），而且与AIEgens的原始荧光相比，其荧光发射效率提高了16倍以上。同时，aie活性mof的发射也可以通过改变AIEgens上的取代基来精细地设计。作为概念证明，所选择的aie活性MOF-2 （LMOF-2）作为一种新型荧光探针用于检测铜离子（Cu2+），具有相当大的响应范围（1-100 nM）和敏感的皮摩尔检测限（550 pM）。更重要的是，基于葡萄糖氧化酶（GOD）催化的LMOF-2/GOD纳米复合材料的级联氧化还原反应，开发了一种荧光异色试纸条，可用于在正常空腹血糖浓度范围（3-8 mM）内的葡萄糖视觉检测，具有良好的特异性和选择性，在实际血清样品中具有很大的应用潜力。
By binding aggregation-induced emission luminogens (AIEgens) with nanoscale ZIF-8, a series of novel luminescent metal–organic frameworks (LMOFs) with good photostability and excellent dispersibility have been facilely fabricated. The developed AIE-active MOFs not only inherit the intriguing AIE properties of AIEgens, including excited-state intramolecular proton transfer (ESIPT) properties, intense solid-state luminescence and large Stokes shifts (115–202 nm), but also show surprisingly boosted fluorescent emission efficiency (over 16 times) when compared with the original fluorescence of AIEgens. Meanwhile, the emission of AIE-active MOFs could also be finely engineered by varying the substituents on AIEgens. And as a proof of concept, the selected AIE-active MOF-2 (LMOF-2) served as a novel fluorescent probe for detecting copper ions (Cu2+), and a considerable response range (1–100 nM) and a sensitive picomolar detection limit (550 pM) were favorably obtained. More importantly, based on a glucose oxidase (GOD) catalyzed cascade redox reaction of LMOF-2/GOD nanocomposites, a fluorescent allochroic test strip was favourably developed for visual detection of glucose within a normal concentration range of fasting blood-glucose in human sera (3–8 mM), and has great potential to be applied in on-site assay of glucose in real serum samples due to its praiseworthy specificity and selectivity.