Prognostic value of myeloperoxidase in patients with chest pain
Prognostic value of myeloperoxidase in patients with chest pain
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DOI：
10.1056/nejmoa035003
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发表时间：
2003-10-23
影响因子：
158.5
通讯作者：
Hazen, SL
中科院分区：
文献类型：
--
作者：
Brennan, M;Penn, MS;Hazen, SL
背景：炎症与急性冠脉综合征的不良后果有关。髓过氧化物酶是一种丰富的白细胞酶，在因心脏原因猝死的患者中出现裂痕或破裂的罪魁祸首病变中会升高。大量证据表明髓过氧化物酶与炎症和心血管疾病之间存在机制联系。方法：我们评估了 604 名连续因胸痛到急诊科就诊的患者的血浆髓过氧化物酶水平作为心血管事件风险预测因子的价值。结果：初始血浆髓过氧化物酶水平可以预测心肌梗死的风险，即使在阴性患者中也是如此 对于肌钙蛋白 T (
BACKGROUND:Inflammation is linked to adverse outcomes in acute coronary syndromes. Myeloperoxidase, an abundant leukocyte enzyme, is elevated in culprit lesions that have fissured or ruptured in patients with sudden death from cardiac causes. Numerous lines of evidence suggest mechanistic links between myeloperoxidase and both inflammation and cardiovascular disease.METHODS:We assessed the value of plasma levels of myeloperoxidase as a predictor of the risk of cardiovascular events in 604 sequential patients presenting to the emergency department with chest pain.RESULTS:Initial plasma myeloperoxidase levels predicted the risk of myocardial infarction, even in patients who are negative for troponin T (