NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: A description of the trial
NSABP-32: Phase III, randomized trial comparing axillary resection with sentinal lymph node dissection: A description of the trial
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DOI：
10.1245/aso.2004.11.909
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发表时间：
2004-03-01
影响因子：
3.7
通讯作者：
Wolmark, N
中科院分区：
文献类型：
--
作者：
Krag, DN;Julian, TB;Wolmark, N
NSABP-32 试验是一项随机 III 期临床试验，旨在比较临床淋巴结阴性乳腺癌患者的前哨淋巴结 (SN) 切除术与传统腋窝淋巴结清扫术。该试验的主要目的是确定仅切除 SN 是否可以提供与腋窝清扫相当的生存和区域控制，同时减少手术相关副作用的程度。为了确保本试验结果的一致性，所有病例均采用标准化的 SN 手术方法。 B32 试验的第二个目的是评估 SN 中发生“隐匿”转移的患者的生存率是否较差。北美 73 家机构正在开展应计项目，有 217 名外科医生正在招募患者。
The NSABP-32 trial is a randomized, phase III clinical trial to compare sentinel node (SN) resection to conventional axillary dissection in clinically node-negative breast cancer patients. The primary aims of the trial are to determine if removal of only SNs provides survival and regional control equivalent to those of axillary dissection, while diminishing the magnitude of surgically related side effects. In order to ensure consistency of the outcomes for this trial, a standardized method of SN surgery has been utilized for all cases. A secondary aim of the B32 trial is to evaluate whether patients with "occult" metastases in the SNs have worse survival. Accrual is taking place at 73 institutions in North America, and 217 surgeons are enrolling patients.