Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk.
Interactions of the intestinal epithelium with the pathogen and the indigenous microbiota: a three-way crosstalk.
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DOI：
10.1155/2008/626827
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发表时间：
2008
影响因子：
--
通讯作者：
McCormick BA
中科院分区：
文献类型：
--
作者：
Srikanth CV;McCormick BA
胃肠道的粘膜表面含有大量与宿主共同进化的共生微生物区系，此外还显示了与宿主最复杂的关系之一。这种关系影响宿主生物学的几个重要方面，包括营养物质的合成、对感染的保护和免疫系统的发展。另一方面，尽管存在几种粘膜防御机制，但志贺氏菌和沙门氏菌等病原体已经进化出复杂的毒力策略来突破这些障碍。来自这些病原体的持续挑战和宿主对抗它们的尝试建立了细胞和分子串扰的动态平衡。即使这种平衡的轻微破坏也可能对宿主有害，导致严重的细菌感染，甚至是炎症性肠病等自身免疫性疾病。一些实验模型系统，包括无菌小鼠和抗生素处理小鼠，已经被不同的研究人员用来研究这种复杂的关系。虽然这只是一个开始，但它有望成为研究这些宿主-微生物关系的一个令人兴奋的时代。
The mucosal surfaces of the gastrointestinal tract harbor a vast number of commensal microbiota that have coevolved with the host, and in addition display one of the most complex relationships with the host. This relationship affects several important aspects of the biology of the host including the synthesis of nutrients, protection against infection, and the development of the immune system. On the other hand, despite the existence of several lines of mucosal defense mechanisms, pathogenic organisms such as Shigella and Salmonella have evolved sophisticated virulence strategies for breaching these barriers. The constant challenge from these pathogens and the attempts by the host to counter them set up a dynamic equilibrium of cellular and molecular crosstalk. Even slight perturbations in this equilibrium may be detrimental to the host leading to severe bacterial infection or even autoimmune diseases like inflammatory bowel disease. Several experimental model systems, including germ-free mice and antibiotic-treated mice, have been used by various researchers to study this complex relationship. Although it is only the beginning, it promises to be an exciting era in the study of these host-microbe relationships.