Relationship Between the Hypothalamic-Pituitary-Thyroid Axis and Alcohol Craving in Alcohol-Dependent Patients: A Longitudinal Study
Relationship Between the Hypothalamic-Pituitary-Thyroid Axis and Alcohol Craving in Alcohol-Dependent Patients: A Longitudinal Study
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DOI：
10.1111/j.1530-0277.2008.00792.x
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发表时间：
2008-12-01
影响因子：
3.2
通讯作者：
Addolorato, Giovanni
中科院分区：
文献类型：
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作者：
Leggio, Lorenzo;Ferrulli, Anna;Addolorato, Giovanni
一些下丘脑-垂体相关激素和酒精渴求之间的关系已经被提出，导致假设一些激素在酒精依赖的神经生物学中的作用。皮质醇、促肾上腺皮质激素、催乳素、促甲状腺激素（TSH）、游离T3、游离T4、生长激素、促卵泡激素、促甲状腺激素（FSH）促黄体生成激素以及管理强迫性饮酒量表（OCDS）和Penn酒精渴望量表（PACS）在基线和12周后在25名当前AD患者中进行评估。患者用巴氯芬（10 mg t.i.d.）在这12周里。基线时TSH与PACS（r = -0.46; p = 0.022）和OCDS评分（r = -0.53; p = 0.007）呈显著负相关。游离T3与OCDS评分之间存在显著的直接相关性（r = 0.44; p = 0.026）。戒断组16例，戒断12周后渴求评分明显降低（P < 0.01）。12周时，未发现TSH与饮酒渴望之间存在显著相关性，但游离T3与OCDS评分仍直接相关（r = 0.60; p = 0.013）。AD患者的酒精渴望与游离T3和TSH之间存在相关性，表明下丘脑-垂体-甲状腺轴可能参与了酒精渴望的神经生物学过程。
A relationship between some hypothalamic-pituitary-related hormones and craving for alcohol has been suggested, leading to hypothesize a role of some hormones in the neurobiology of alcohol dependence. Investigating this association in alcohol-dependent (AD) patients was the aim of this preliminary and exploratory study.Cortisol, adrenocorticotropic hormone, prolactin, thyroid-stimulating hormone (TSH), free T3, free T4, growth hormone, follicle-stimulating hormone, luteinizing hormone as well as administering the Obsessive-Compulsive Drinking Scale (OCDS) and Penn Alcohol Craving Scale (PACS) were assessed at baseline and after 12 weeks in 25 current AD patients. Patients were treated with baclofen (10 mg t.i.d.) for these 12 weeks. Sixteen patients remained totally abstinent for 12 weeks.At baseline, a significant inverse correlation was found between TSH and PACS (r = -0.46; p = 0.022) and OCDS scores (r = -0.53; p = 0.007). A significant direct correlation was found between free T3 and OCDS score (r = 0.44; p = 0.026). In the 16 abstinent patients, craving scores were significantly decreased at 12 weeks (p < 0.01). At 12 weeks, no significant correlation was found between TSH and craving, but free T3 remained directly correlated with OCDS score (r = 0.60; p = 0.013).A relationship between alcohol craving and free T3 and TSH was demonstrated in AD patients, suggesting the potential involvement of the hypothalamic-pituitary-thyroid axis in the neurobiology of alcohol craving.