Evidence of Nicotine-Induced, Curare-Insensitive, Behavior in Planarians.
Evidence of Nicotine-Induced, Curare-Insensitive, Behavior in Planarians.
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涡虫中尼古丁诱导的箭毒不敏感行为的证据。
DOI：
10.1007/s11064-015-1512-6
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发表时间：
2015
影响因子：
4.4
通讯作者：
Baker,Debra
中科院分区：
文献类型：
--
作者：
Pagán,OnéR;Montgomery,Erica;Deats,Sean;Bach,Daniel;Baker,Debra
Planarians正在迅速发展成为药理学和神经科学研究中非常有用的研究对象。在这里，我们报告说，箭毒，一种胆碱能烟碱受体拮抗剂，在尼古丁和箭毒等摩尔浓度（1 mM）时，使尼古丁诱导的Planarian类扁虫样运动（pSLM）增加高达50%，而箭毒单独使用时不会诱导显著的pSLM。我们的数据的最简单的解释是，在我们的实验生物体中存在尼古丁诱导的对箭毒不敏感的行为。据我们所知，这是第一份关于尼古丁对任何生物体的不敏感效应的报告。
Planarians are rapidly developing into very useful research subjects in pharmacology and neuroscience research. Here we report that curare, a cholinergic nicotinic receptor antagonist, alleviates the nicotine-induced planarian seizure-like movements (pSLM) by up to 50 % at equimolar concentrations of nicotine and curare (1 mM), while curare alone does not induce significant pSLMs. The simplest interpretation of our data is that there are nicotine induced behaviors insensitive to curare in our experimental organism. To the best of our knowledge, this is the first report on curare-insensitive, nicotine-induced effects in any organism.