Analysis of the spontaneous variability of ventricular arrhythmias: consecutive ambulatory electrocardiographic recordings of ventricular tachycardia.
Analysis of the spontaneous variability of ventricular arrhythmias: consecutive ambulatory electrocardiographic recordings of ventricular tachycardia.
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室性心律失常的自发变异性分析：室性心动过速的连续动态心电图记录。
DOI：
10.1016/0002-9149(85)90568-5
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Roberts,R
中科院分区：
文献类型：
--
作者：
Pratt,CM;Slymen,DJ;Wierman,AM;Young,JB;Francis,MJ;Seals,AA;Quinones,MA;Roberts,R
报告了对 110 名患有室性心动过速 (VT) 患者的队列中复杂室性心律失常变异性进行分析的结果。所有患者均参加研究性抗心律失常药物试验，并平均连续 4 天进行安慰剂动态心电图记录，作为本研究的数据库。使用结合方差分析的统计方法，计算室性早搏、双联和VT的最小减少百分比，以建立“药物效应”而不是显着性水平0.05的变异性。还分析了对预后重要的组中室性心律失常的相对变异性：(1) 冠状动脉疾病 (CAD) (n = 57) 与无 CAD (n = 53)； (2) 左心室射血分数为 40% 或以下的患者 (n = 52) 与射血分数大于 40% 的患者 (n = 58)； (3) 频繁进行 VT 的患者（每天 10 次或以上，n = 63）与不频繁 VT 的患者（n = 47）。多元回归分析显示，患有 CAD 的患者室性早搏复合波变异性显着高于非 CAD 患者 (p < 0.01)。此外，频繁进行 VT 运行的患者的 VT 变异性比之前小型研究中报告的要大，因此需要更大程度地降低 VT 才能确定药物作用。室性心律失常的变异性本身是否是心源性猝死的独立危险因素尚不清楚。
Results are reported of analysis of the variability of complex ventricular arrhythmias in a cohort of 110 patients selected for the presence of ventricular tachycardia (VT). All patients were enrolled in investigational antiarrhythmic drug trials and had an average of 4 consecutive days of placebo ambulatory electrocardiographic recording to serve as the database for this study. Using a statistical approach incorporating analysis of variance, the minimum percent reductions of ventricular premature complexes, couplets and VT were calculated to establish “drug effect” rather than variability at a significance level of 0.05. The relative variability of ventricular arrhythmias in prognostically important groups was also analyzed: (1) coronary artery disease (CAD) (n = 57) vs no CAD (n = 53); (2) patients with a left ventricular ejection fraction of 40% or less (n = 52) vs those with an ejection fraction greater than 40% (n = 58); and (3) patients with frequent runs of VT (10 or more runs/day, n = 63) vs infrequent VT (n = 47). Multiple regression analysis revealed that patients with CAD have significantly greater premature ventricular complex variability than patients without CAD (p < 0.01). Also, patients with frequent VT runs have greater VT variability than that previously reported in smaller studies, thus requiring greater VT reductions to establish drug effect. Whether the variability of ventricular arrhythmia is itself an independent risk factor for sudden cardiac death is unknown.