Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats
Renal effects of a new member of adrenomedullin family, adrenomedullin2, in rats
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DOI：
10.1016/j.ejphar.2004.06.039
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发表时间：
2004-08-16
影响因子：
5
通讯作者：
Abe, Y
中科院分区：
文献类型：
--
作者：
Fujisawa, Y;Nagai, Y;Abe, Y
在哺乳动物中发现了肾上腺髓质素家族的新成员肾上腺髓质素2。研究了肾上腺髓质素2对大鼠肾血流动力学和尿形成的影响。肾内动脉输注肾上腺髓质素2以30,100和300 pmol/ kg/min的速率降低血压和增加心率呈剂量依赖性。100 pmol/kg/min肾上腺髓质素2输注显著增加肾血流量和尿流量。在较高的输注速率（300 pmol/kg/min）下，肾上腺髓质素2显著减少尿流量。以100 pmol/kg/min持续肾内输注肾上腺髓素2显著增加肾血流量，从6.7+/-0.5 ml/min增加到8.8+/-0.5 ml/min，肾血管阻力从16+/-1降低到11+/-1 mm Hg mm/ml。尿流量从21.5+/-4.9增加到36.2+/-8.5 muEq/min，尿钠排泄量从2.3+/-0.9增加到4.9+/-1.4 muEq/min。血压、心率和肾小球滤过率没有变化。输注相同剂量的肾上腺髓质素也增加了肾血流量（6.8+/-0.4-8.8+/-0.6 ml/min）、尿流量（25.4+/-3.2-42.8+/-9.4 muEq/min）和尿钠排泄量（2.8+/-0.6-6.5+/-1.2 muEq/min），降低了肾血管阻力（15+/-1-11+/-1 mmHg min/ml），并没有改变肾小球滤过率。因此，肾上腺髓质素2诱导的肾作用与肾上腺髓质素相似。这些数据提示肾上腺髓质素2可能在肾脏血流动力学和尿形成的调节中起重要作用。(C) 2004 Elsevier B.V.版权所有
A new member of the adrenomedullin family, adrenomedullin2, was identified in mammals. The effects of adrenomedullin2 on renal hemodynamics and urine formation were examined in rats. Intrarenal arterial infusion of adrenomedullin2 at rates of 30, 100 and 300 pmol/ kg/min decreased blood pressure and increased heart rate in a dose-dependent fashion. Adrenomedullin2 infusion at 100 pmol/kg/min significantly increased renal blood flow and urine flow. At the higher infusion rate (300 pmol/kg/min), adrenomedullin2 significantly decreased urine flow. Continuous intrarenal infusion of adrenomedullin2 at 100 pmol/kg/min significantly increased renal blood flow from 6.7+/-0.5 to 8.8+/-0.5 ml/min and decreased renal vascular resistance from 16+/-1 to 11+/-1 mm Hg mm/ml. Urine flow was significantly increased from 21.5+/-4.9 to 36.2+/-8.5 mul/min and urinary excretion of sodium was increased from 2.3+/-0.9 to 4.9+/-1.4 muEq/min. Blood pressure, heart rate and glomerular filtration rate did not change. Infusion of a similar dose of adrenomedullin also increased renal blood flow (6.8+/-0.4-8.8+/-0.6 ml/min), urine flow (25.4+/-3.2-42.8+/-9.4 mul/min) and urinary excretion of sodium (2.8+/-0.6-6.5+/-1.2 muEq/min), decreased renal vascular resistance (15+/-1-11+/-1 mmHg min/ml) and did not alter glomerular filtration rate. Thus, the renal actions induced by adrenomedullin2 were similar to those of adrenomedullin. These data suggest that adrenomedullin2 may play an important role in the regulation of renal hemodynamics and urine formation. (C) 2004 Elsevier B.V. All rights reserved.