Fabrication of hollow-structured composite microspheres with amphiphilic and superparamagnetic properties
Fabrication of hollow-structured composite microspheres with amphiphilic and superparamagnetic properties
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DOI：
10.1039/c5ra28095h
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发表时间：
2016-02
期刊：
影响因子：
3.9
通讯作者：
Xiaohui Zhan;Liqin Xie;Hongli Chen;Yao Wu;Z. Gu
中科院分区：
文献类型：
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作者：
Xiaohui Zhan;Liqin Xie;Hongli Chen;Yao Wu;Z. Gu
溶剂腐蚀法是制备具有中空结构的多功能纳米微球的常用方法。在本研究中，我们报道了一种制备中空复合微球的简便方法，该微球具有两亲性和超顺磁性。以P（St-AA）/Fe_3O_4/PAA磁性复合微球为模板，选择性刻蚀P（St-AA），得到了具有亲水性聚合物刷壳的疏水中空结构。研究了刻蚀对纳米复合材料的形貌、中空结构、饱和磁化强度、两亲性和细胞相容性的影响。表征结果表明，所得中空复合微球具有球形结构、高饱和磁化强度、两亲性和良好的细胞相容性，有望作为磁共振成像和药物释放系统的潜在生物材料。
Solvent etching is a general method for the fabrication of hollow-structured nano/micro-spheres with multiple functions. In this study, we report a facile route for the preparation of hollow composite microspheres, which are amphiphilic and superparamagnetic. In a template of magnetic composite microspheres, P(St-AA)/Fe3O4/PAA, P(St-AA) was selectively etched, resulting in a hydrophobic hollow structure with a shell of hydrophilic polymeric brushes. The effects of etching on the morphology, hollow structure, saturation magnetization, amphiphilic property and cytocompatibility were investigated. Characterization showed that the hollow composite microspheres obtained possessed a well-defined spherical structure, a high saturation magnetization, amphiphilic properties and good cytocompatibility, making them promising as a potential biomaterial in magnetic resonance imaging and drug delivery systems.