Prevalence and Disease Burden of Primary Restless Legs Syndrome: Results of a General Population Survey in the United States
Prevalence and Disease Burden of Primary Restless Legs Syndrome: Results of a General Population Survey in the United States
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DOI：
10.1002/mds.23430
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发表时间：
2011-01-01
影响因子：
8.6
通讯作者：
Calloway, Michael
中科院分区：
文献类型：
--
作者：
Allen, Richard P.;Bharmal, Murtuza;Calloway, Michael
评估美国原发性不宁腿综合征（RLS）的患病率、疾病负担和费用。2007年，来自美国代表性小组的313，000名受试者中有61，792名（20%）完成了一项在线“全球意见”调查，确定了报告RLS所有四个诊断特征的受访者。4，484人符合所有标准。随机选择1,400人完成问卷调查，以排除那些诊断为可能继发性RLS的人。那些没有诊断出与继发性RLS相关的患者被要求完成剑桥-霍普金斯RLS问卷，以排除RLS模拟。估计以下组的患病率：（1）RLS症状，（2）原发性RLS，和（3）原发性RLS患者（症状>= 2/周，伴有中度至重度痛苦）。主要RLS完成了一项更大的在线调查，包括IRLS、EuroQol、工作效率和活动障碍问卷以及有关医疗资源使用的问题。经验证的诊断工具和排除可能导致RLS的医学状况提供了非常保守的美国人口普查加权患病率估计，原发性RLS为2.4%，原发性RLS患者为1.5%。大约33%的受访者有RLS的医生诊断。原发性RLS患者的平均生产力损失为1天/周。所有RLS相关的费用随着RLS症状的严重程度而增加，健康状况、睡眠障碍和工作效率的下降越来越显著。即使是这种非常保守的方法也发现RLS在这一队列中很常见，诊断不足，并带来了重大的个人和社会负担。(C)2010年运动障碍协会
To assess prevalence, disease burden, and costs of primary Restless Legs Syndrome (RLS) in the US. In 2007, 61,792 (20%) of 313,000 subjects from a representative US panel completed an online "global opinions" survey identifying respondents reporting all four diagnostic features of RLS. 4,484 met all criteria. 1,400 were randomly selected to complete a questionnaire to exclude those with diagnoses indicating possible secondary RLS. Those that did not have diagnoses associated with secondary RLS were asked to complete the Cambridge-Hopkins RLS questionnaire to exclude RLS mimics. Prevalence was estimated for the following groups: (1) RLS symptomatic, (2) primary RLS, and (3) primary RLS sufferers (symptoms >= 2/wk with moderate-to-severe distress). The primary RLS completed a larger online survey including the IRLS, EuroQol, Work Productivity and Activity Impairment questionnaire, and questions about healthcare resource use. The validated diagnostic tools and exclusion of medical conditions likely to cause RLS provide a very conservative estimate of US census-weighted prevalence of 2.4% for primary RLS and 1.5% for primary RLS sufferers. About 33% of respondents had a physician diagnosis of RLS. Primary RLS sufferers had a mean productivity loss of 1 day/wk. All RLS-related costs increased with RLS symptom severity, with increasingly significant decrements in health status, sleep disturbance, and work productivity. Even this very conservative approach finds RLS in this cohort to be common, under-diagnosed, and carried a significant personal and social burden. (C) 2010 Movement Disorder Society