Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population.
Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population.
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pTEN/AKT/mTOR 信号通路基因的遗传多态性与癌症风险的关联：亚洲人群的荟萃分析
DOI：
10.1038/s41598-017-17250-z
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发表时间：
2017-12-19
影响因子：
4.6
通讯作者：
Wei M
中科院分区：
文献类型：
--
作者：
Zhang Z;Chen Q;Zhang J;Wang Y;Hu X;Yin S;He M;Guan S;Qin W;Xiao Q;Zhao H;Yao W;Wu H;Wei M
pTEN/AKT/mTOR信号通路在平衡细胞增殖、分化和存活中起关键作用。近年来研究pTEN/AKT/mTOR通路核心基因多态性与肿瘤易感性的关系；然而，结果是不确定的。因此，通过对31项符合条件的研究的文献进行系统的meta分析，评估5个snp （mTOR rs2295080和rs2536， AKT1 rs2494750和rs2494752， pTEN rs701848）与癌症风险之间的关系。结果显示rs2295080 TG、GG基因型和GG/TG基因型与总体癌症[TG vs.TT: OR(95% CI) = 0.82(0.76, 0.89), GG/TG vs.TT: OR(95% CI) = 0.82(0.76, 0.88), GG vs. TG/TT: OR(95% CI) = 0.67(0.51, 0.88)]和泌尿系统癌和消化系统癌亚组]的风险显著降低。此外，SNP rs701848 CC、TC基因型在显性模型[CC/TC vs. TT: OR(95% CI) = 1.25(1.15, 1.36)]和隐性模型[CC vs. TC/TT: OR(95% CI) = 1.20(1.09, 1.32)]、消化系统癌和泌尿系统癌的总体风险均显著增加。此外，rs2494752的AG基因型和GG/AG基因型与癌症风险增加相关。因此，本荟萃分析为亚洲人群提供了致癌的遗传风险因素和最有效的癌症患病率估计。
The pTEN/AKT/mTOR signaling pathways play a critical role in balancing cell proliferation, differentiation, and survival. Recent studies researched the associations of core genes in the pTEN/AKT/mTOR pathway polymorphisms with the cancer susceptibility; however, the results are inconclusive. Therefore, a systematically meta-analysis was performed to evaluate the association between the five SNPs (mTOR rs2295080 and rs2536, AKT1 rs2494750 and rs2494752, pTEN rs701848) and cancer risk by systematic review of the literature in 31 eligible studies. The results showed a significant decreased risk between rs2295080 TG, GG genotype, and GG/TG genotypes and overall cancer [TG vs.TT: OR(95% CI) = 0.82(0.76, 0.89), GG/TG vs. TT: OR(95% CI) = 0.82(0.76, 0.88), and GG vs. TG/TT: OR(95% CI) = 0.67(0.51, 0.88)] and the subgroup of urinary system cancer and digestive system cancer. Moreover, the SNP rs701848 CC, TC genotype showed significantly increased the overall cancer risk both in dominant model [CC/TC vs. TT: OR(95% CI) = 1.25(1.15, 1.36)] and recessive model [CC vs. TC/TT: OR(95% CI) = 1.20(1.09, 1.32)], and digestive system cancer and urinary system cancer. In addition, AG genotype and GG/AG genotype of rs2494752 was associated with increased risk of cancer. Therefore, this meta-analysis provided genetic risk factors for carcinogenesis and the most valid cancer prevalence estimate for Asian population.
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影响因子：
--
作者：
Zining J;Lu X;Caiyun H;Yuan Y
通讯作者：
Yuan Y
影响因子：
2.6
作者：
Huang, Lizhen;Huang, Jie;Fang, Yongjun
通讯作者：
Fang, Yongjun
影响因子：
3.3
作者：
Edinger, AL;Thompson, CB
通讯作者：
Thompson, CB
影响因子：
5.3
作者：
Fingar, DC;Richardson, CJ;Blenis, J
通讯作者：
Blenis, J
DOI：
10.1016/j.jamcollsurg.2009.12.008
发表时间：
2010-05
影响因子：
5.2
作者：
Johnson, Sara M.;Gulhati, Pat;Rampy, Bill A.;Han, Yimei;Rychahou, Piotr G.;Doan, Hung Q.;Weiss, Heidi L.;Evers, B. Mark
通讯作者：
Evers, B. Mark