Oxyntomodulin stimulates intestinal glucose uptake in rats.
Oxyntomodulin stimulates intestinal glucose uptake in rats.
复制标题
泌酸调节素刺激大鼠肠道葡萄糖的摄取。
DOI：
10.1053/gast.1997.v112.pm9178688
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发表时间：
1997
期刊：
影响因子：
29.4
通讯作者：
ReeveJr,JR
中科院分区：
文献类型：
--
作者：
Collie,NL;Zhu,Z;Jordan,S;ReeveJr,JR
背景与目的肠胰高血糖素肽长期以来被认为是肠道适应的介质，包括粘膜生长和营养吸收能力。胃泌酸调节素是肠胰高血糖素的一种生物活性形式，它的输注将刺激葡萄糖和氨基酸的摄取，这一假设被测试，并将其效果与胰高血糖素的效果进行了比较。（0.47 nmol x kg（-1）x h[-1]）或胰高血糖素（0.88 nmol x kg（-1）x h[-1]）持续7天，并测量血浆激素水平。在死亡时，肠道尺寸和刷状缘摄取的D-葡萄糖和L-脯氨酸进行了测量，使用在体外外翻sleeve technique. EMPTS血浆肠胰高血糖素和胰高血糖素水平分别增加了4倍和12倍，但没有影响的食物摄入量，体重，或肠道尺寸。相比之下，胃泌酸调节素和胰高血糖素显著刺激总肠葡萄糖摄取能力，分别超过对照组的44%和53%。胃泌酸调节素最有效地增强了回肠的葡萄糖吸收（215%），而胰高血糖素的最大作用是在空肠（63%-85%）。然而，无论是肽影响脯氨酸uptake. CONCLUSION这些结果支持一个新的，具体的行动胃泌酸调节素在肠道适应作为葡萄糖摄取刺激剂，并确认胰高血糖素作为葡萄糖摄取的调节剂的作用。（胃肠病学1997年6月;112（6）：1961-70）
BACKGROUND & AIMSEnteroglucagon peptides have long been proposed as mediators of intestinal adaptation, including mucosal growth and nutrient absorptive capacity. The hypothesis that infusions of oxyntomodulin, a bioactive form of enteroglucagon, would stimulate glucose and amino acid uptake was tested and its effects were compared with those of glucagon.METHODSRats were infused intravenously via minipumps with either saline, rat oxyntomodulin (0.47 nmol x kg(-1) x h[-1]), or glucagon (0.88 nmol x kg(-1) x h[-1]) for 7 days, and plasma hormone levels were measured. At death, intestinal dimensions and brush border uptake of D-glucose and L-proline were measured using an in vitro everted sleeve technique.RESULTSPlasma enteroglucagon and glucagon levels were increased 4- and 12-fold, respectively, but there were no effects on food intake, body weight, or intestinal dimensions. In contrast, oxyntomodulin and glucagon significantly stimulated total intestinal glucose uptake capacity by 44% and 53%, respectively, over controls. Oxyntomodulin most potently enhanced glucose uptake in the ileum (215%), whereas glucagon's greatest effect was in the jejunum (63%-85%). However, neither peptide affected proline uptake.CONCLUSIONSThese results support a new, specific action for oxyntomodulin in intestinal adaptation as a glucose uptake stimulator and confirm glucagon's role as a regulator of glucose uptake. (Gastroenterology 1997 Jun;112(6):1961-70)