Localisation of phosphatidylethanolamine-binding protein in the brain and other tissues of the rat
Localisation of phosphatidylethanolamine-binding protein in the brain and other tissues of the rat
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DOI：
10.1007/s004419900113
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发表时间：
1999-12-01
影响因子：
3.6
通讯作者：
Hall, L
中科院分区：
文献类型：
--
作者：
Frayne, J;Ingram, C;Hall, L
磷脂酰乙醇胺结合蛋白（PEBP）是一种高度保守的21至23 kDa碱性蛋白，在体外对磷脂酰乙醇胺表现出优先亲和力。先前的研究集中在大脑和男性生殖道中的PEEP，其中已提出PEEP在膜生物发生中发挥作用。在目前更全面的研究中，大鼠PEEP转录本和蛋白质已被发现在所有组织中的检查，虽然组织之间的水平有很大的差异。然而，在细胞水平上，PEEP表达是神秘的，被限制在各种高度专门化的神经元和非神经元细胞类型。这种多样性的性质，从少突胶质细胞到浆细胞，虽然不排除PEEP在某些细胞类型的膜生物发生中的作用，但这意味着这不是其他细胞类型的主要功能。
Phosphatidylethanolamine-binding protein (PEBP is a highly-conserved 21- to 23-kDa basic protein that shows preferential affinity in vitro for phosphatidylethanolamine. Previous studies have focussed on PEEP in the brain and male reproductive tract where it has been proposed to play a role in membrane biogenesis. In the present more comprehensive study, rat PEEP transcripts and protein have been found to be expressed in all tissues examined, although the levels vary considerably between tissues. However, at the cellular level, PEEP expression is enigmatic, being restricted to a diverse range of highly specialised neuronal and non-neuronal cell types. The nature of this diversity, ranging from oligodendrocytes to plasma cells, whilst not precluding a role for PEEP in membrane biogenesis in some cell types, would imply that this is not the major function in others.