Effects of hyperthermia therapy on the liver. II. Morphological observations.
Effects of hyperthermia therapy on the liver. II. Morphological observations.
复制标题
热疗对肝脏的影响。
DOI：
10.1136/jcp.29.1.1
复制
发表时间：
1976
影响因子：
3.4
通讯作者：
Dr E. J. Wills
中科院分区：
文献类型：
--
作者：
E. Wills;And J. M. FINDLAY;J. McManus;Dr E. J. Wills
本文对三例晚期恶性肿瘤患者在外源性热疗过程中的肝活检标本进行了光镜和电镜观察。在两个病人的实质细胞表现出轻微肿胀或核改变，通过光学显微镜，在精细结构水平，大量的自噬空泡，高尔基体和内质网扩张，和大的胞质空泡。病例3的肝脏也有类似的变化，但形式更为严重，伴有实质细胞坏死和胆汁淤积，他在高温后24小时出现黄疸。研究结果进行了讨论，在早期帐户的肝脏高温后的变化，并考虑功能的影响。
Liver biopsy specimens obtained from three patients during treatment of advanced malignant disease by exogenous hyperthermia were studied by light and electron microscopy. In two patients the parenchymal cells showed either slight swelling or nuclear alterations by light microscopy and, at the fine structural level, large numbers of autophagic vacuoles, dilatation of Golgi elements and endoplasmic reticulum, and large cytoplasmic vacuoles. Similar changes, but in much more severe form together with parenchymal cell necrosis and cholestasis, were seen in the liver of case 3, who developed jaundice 24 hours after hyperthermia. The findings are discussed in relation to earlier accounts of liver changes following hyperthermia, and the functional implications are considered.